This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human IGF-I, Animal-Free Recombinant Protein, PeproTech
catalog :
AF-100-11-1MG
quantity :
1 mg
price :
US 318.00
citations: 37
Reference
McAloney C, Makkawi R, Budhathoki Y, Cannon M, Franz E, Gross A, et al. Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. Cell Oncol (Dordr). 2023;: pubmed publisher
Sissaoui S, Egginton S, Ting L, Ahmed A, Hewett P. Hyperglycaemia up-regulates placental growth factor (PlGF) expression and secretion in endothelial cells via suppression of PI3 kinase-Akt signalling and activation of FOXO1. Sci Rep. 2021;11:16344 pubmed publisher
James O, Selvaraj B, Magnani D, Burr K, Connick P, Barton S, et al. iPSC-derived myelinoids to study myelin biology of humans. Dev Cell. 2021;56:1346-1358.e6 pubmed publisher
Mehta A, Gregory J, Dando O, Carter R, Burr K, Nanda J, et al. Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis. Acta Neuropathol. 2021;141:257-279 pubmed publisher
Tiburcy M, Meyer T, Liaw N, Zimmermann W. Generation of Engineered Human Myocardium in a Multi-well Format. STAR Protoc. 2020;1:100032 pubmed publisher
García León J, García Diaz B, Eggermont K, Cáceres Palomo L, Neyrinck K, Madeiro da Costa R, et al. Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells. Nat Protoc. 2020;15:3716-3744 pubmed publisher
Montiel V, Bella R, Michel L, Esfahani H, De Mulder D, Robinson E, et al. Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Sci Transl Med. 2020;12: pubmed publisher
Sharma R, Smits I, de la Vega L, Lee C, Willerth S. 3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres. Front Bioeng Biotechnol. 2020;8:57 pubmed publisher
Somchai P, Phongkitkarun K, Kueanjinda P, Jamnongsong S, Vaeteewoottacharn K, Luvira V, et al. Novel Analytical Platform For Robust Identification of Cell Migration Inhibitors. Sci Rep. 2020;10:931 pubmed publisher
Li Q, Huang Q. Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition. PLoS ONE. 2019;14:e0223724 pubmed publisher
Choucair A, Pham T, Omarjee S, Jacquemetton J, Kassem L, Tredan O, et al. The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer. Oncogene. 2019;38:4015-4027 pubmed publisher
Uhlendorf T, Nuryyev R, Kopyov A, Ochoa J, Younesi S, Cohen R, et al. Efficacy of Two Delivery Routes for Transplanting Human Neural Progenitor Cells (NPCs) Into the Spastic Han-Wistar Rat, a Model of Ataxia. Cell Transplant. 2017;26:259-269 pubmed publisher
Kido K, Ato S, Yokokawa T, Makanae Y, Sato K, Fujita S. Acute resistance exercise-induced IGF1 expression and subsequent GLUT4 translocation. Physiol Rep. 2016;4: pubmed publisher
Duan X, Qiao M, Bei F, Kim I, He Z, Sanes J. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron. 2015;85:1244-56 pubmed publisher
Pan T, Sun J, Hu J, Hu Y, Zhou J, Chen Z, et al. Cytohesins/ARNO: the function in colorectal cancer cells. PLoS ONE. 2014;9:e90997 pubmed publisher
Taniguchi T, Tanaka S, Ishii A, Watanabe M, Fujitani N, Sugeo A, et al. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. J Biol Chem. 2013;288:29934-42 pubmed publisher
Ni F, Sun R, Fu B, Wang F, Guo C, Tian Z, et al. IGF-1 promotes the development and cytotoxic activity of human NK cells. Nat Commun. 2013;4:1479 pubmed publisher
Jackson T, Verrier J, Kochanek P. Anthraquinone-2-sulfonic acid (AQ2S) is a novel neurotherapeutic agent. Cell Death Dis. 2013;4:e451 pubmed publisher
Kawamura K, Chen Y, Shu Y, Cheng Y, Qiao J, Behr B, et al. Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors. PLoS ONE. 2012;7:e49328 pubmed publisher
Nakaguchi K, Jinnou H, Kaneko N, Sawada M, Hikita T, Saitoh S, et al. Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain. Stem Cells Int. 2012;2012:915160 pubmed publisher
Van Valen F, Harrer H, Hotfilder M, Dirksen U, Pap T, Gosheger G, et al. A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells. Sarcoma. 2012;2012:782970 pubmed publisher
Kong Z, Zhu X, Zhang S, Wu J, Luo Y. Phase contrast microscopy of living cells within the whole lens: spatial correlations and morphological dynamics. Mol Vis. 2012;18:2165-73 pubmed
Shiba Y, Fernandes S, Zhu W, Filice D, Muskheli V, Kim J, et al. Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature. 2012;489:322-5 pubmed publisher
Ferro F, Spelat R, D Aurizio F, Puppato E, Pandolfi M, Beltrami A, et al. Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics. PLoS ONE. 2012;7:e41774 pubmed publisher
Bill A, Schmitz A, König K, Heukamp L, Hannam J, Famulok M. Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells. PLoS ONE. 2012;7:e41179 pubmed publisher
Bernacchioni C, Cencetti F, Blescia S, Donati C, Bruni P. Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation. Skelet Muscle. 2012;2:15 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Meyer A, Hughes Alford S, Kay J, Castillo A, Wells A, Gertler F, et al. 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. J Cell Biol. 2012;197:721-9 pubmed publisher
Bitar M, Al Mulla F. ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes. Dis Model Mech. 2012;5:375-88 pubmed publisher
Merceron C, Portron S, Vignes Colombeix C, Rederstorff E, Masson M, Lesoeur J, et al. Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: potential application to cartilage regenerative medicine. Stem Cells. 2012;30:471-80 pubmed publisher
Sarfstein R, Pasmanik Chor M, Yeheskel A, Edry L, Shomron N, Warman N, et al. Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells. J Biol Chem. 2012;287:2766-76 pubmed publisher
Chang C, Kazmin D, Jasper J, Kunder R, Zuercher W, McDonnell D. The metabolic regulator ERR?, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell. 2011;20:500-10 pubmed publisher
Chen C, Sarbassov D. The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2. J Biol Chem. 2011;286:40386-94 pubmed publisher
Morimura S, Takahashi K. Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I. Int J Cell Biol. 2011;2011:615912 pubmed publisher
Alva J, Lee G, Escobar E, Pyle A. Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells. Stem Cells. 2011;29:1952-62 pubmed publisher
Sarfstein R, Bruchim I, Fishman A, Werner H. The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway. PLoS ONE. 2011;6:e24468 pubmed publisher
Medyouf H, Gusscott S, Wang H, Tseng J, Wai C, Nemirovsky O, et al. High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. J Exp Med. 2011;208:1809-22 pubmed publisher
product information
Product Type :
Protein
Product Name :
Human IGF-I, Animal-Free Recombinant Protein, PeproTech
Catalog # :
AF-100-11-1MG
Quantity :
1 mg
Price :
US 318.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
Functional Assay: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but has a much higher growth-promoting activity. A variety of cellular responses are induced by IGF1, including cell proliferation, differentiation, migration, and survival. Further, IGF1 is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types in muscle, bone, and cartilage tissue. IGF1 stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regards to enhancing glucose uptake. In circulation, IGFs are predominantly bound to binding proteins (IGFBPs) which prolong the half-life of the IGFs and play a role in delivering them to target tissues. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death. Moreover, mature human IGF-I is 100% homologous with bovine and porcine proteins. Low levels of IGF1 have been linked to Alzheimer's disease. IGF1 is processed from a precursor, bound by a specific receptor, and secreted. Defects in the IGF1 gene are a cause of insulin-like growth factor 1 deficiency and several transcript variants encoding different isoforms have been found.
Format :
Lyophilized
Applications w/Dilutions :
Functional Assay: Assay-dependent
Aliases :
C730016P09Rik; class 1 insulin-like growth factor I preproprotein; class 2 insulin-like growth factor I preproprotein; H-IGF-1; IBP1; IGF; IGF1; Igf-1; IGF1A; IGFI; Igf-I; IGFIa; IGF-IA; IGF-IB; insulin growth factor-1; Insulin like growth factor; insulin like growth factor 1; insulin-like growth factor 1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor I; insulin-like growth factor I (somatomedin C); insulin-like growth factor IB; mechano growth factor; MGF; M-IGF-1; OTTHUMP00000195084; prepro-IGF-I; prepro-insulin-like growth factor I; R-IGF-1; somatomedin; Somatomedin C; Somatomedin-C
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA