CD35 Monoclonal Antibody (E11), Alexa Fluor 488 | Invitrogen A51002 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD35 Monoclonal Antibody (E11), Alexa Fluor 488

catalog :

A51002

quantity :

100Tests

price :

US 227

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

E11

reactivity :

human

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

CD35 Monoclonal Antibody (E11), Alexa Fluor 488

Catalog # :

A51002

Quantity :

100Tests

Price :

US 227

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL/1x10^6 cells

Species :

Human

Clone :

E11

Isotype :

IgG1

Storage :

4° C, store in dark

Description :

CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized. An additional secreted form of CD35 have also been described but has not been fully characterized.

Immunogen :

Intact human monocytes

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL/1x10^6 cells

Aliases :

CR1