A20 Monoclonal Antibody (D13H3) | Invitrogen A16695 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

A20 Monoclonal Antibody (D13H3)

catalog :

A16695

quantity :

100µL

price :

US 309.00

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

D13H3

reactivity :

human

application :

western blot, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

A20 Monoclonal Antibody (D13H3)

Catalog # :

A16695

Quantity :

100µL

Price :

US 309.00

Clonality :

Monoclonal

Purity :

purified

Host :

Rabbit

Reactivity :

Human

Applications :

Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Species :

Human

Clone :

D13H3

Isotype :

IgG

Storage :

-20°C

Description :

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

Immunogen :

recombinant protein specific to the amino terminus terminus of human A20/TNFAIP3 protein.

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Aliases :

A20, OTUD7C, TNFA1P2, OTU domain-containing protein 7C, TNF alpha-induced protein 3, TNFAIP3 (A20), putative DNA-binding protein A20, tumor necrosis factor alpha-induced protein 3, tumor necrosis factor inducible protein A20, zinc finger protein A20