Tau Monoclonal Antibody (Tau46) | Invitrogen A16621 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tau Monoclonal Antibody (Tau46)

catalog :

A16621

quantity :

100 µl

price :

US 325

clonality :

monoclonal

host :

mouse

clone name :

Tau46

reactivity :

human, mouse, fruit fly

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

citations: 4

Published Application/Species/Dilution	Reference
western blot; fruit fly; fig 2	Ando K, Maruko-Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima K. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity. PLoS Genet. 2016;12:e1005917 pubmed publisher
western blot; fruit fly; fig 3	Iijima-Ando K, Sekiya M, Maruko-Otake A, Ohtake Y, Suzuki E, Lu B, et al. Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. PLoS Genet. 2012;8:e1002918 pubmed publisher
western blot; mouse; 1:50; fig 3	Sahara N, Deture M, Ren Y, Ebrahim A, Kang D, Knight J, et al. Characteristics of TBS-extractable hyperphosphorylated tau species: aggregation intermediates in rTg4510 mouse brain. J Alzheimers Dis. 2013;33:249-63 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100	Yokota O, Terada S, Ishizu H, Tsuchiya K, Kitamura Y, Ikeda K, et al. NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC). Acta Neuropathol. 2002;104:333-41 pubmed

product information

Product Type :

A16621

Product Name :

Tau Monoclonal Antibody (Tau46)

Catalog # :

A16621

Quantity :

100 µl

Price :

US 325

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Immunofluorescence, Immunohistochemistry and Western Blot

Species :

Clone :

Tau46

Gene Identification :

Entrez: 4137; Uniprot: P10636

Isotype :

IgG

Storage :

-20°C

Description :

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Immunogen :

bovine Tau

Format :

Liquid; 0.01 M HEPES, 100 µg/ml BSA, 50 % glycerol, 0.15 M NaCl, no preservative

Applications w/Dilutions :

IF Assay Dependent, IHC Assay Dependent, WB Assay Dependent

Aliases :

MAPT, Microtubule-associated protein tau, MTBT1, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau