CD81 Monoclonal Antibody (M38), PE | Invitrogen A15781 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD81 Monoclonal Antibody (M38), PE

catalog :

A15781

quantity :

100 tests

price :

US 282

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

M38

reactivity :

human, cat

application :

flow cytometry

citations: 1

Reference
Tubita V, Seguí Barber J, Lozano J, Bañón Maneus E, Rovira J, Cucchiari D, et al. Effect of immunosuppression in miRNAs from extracellular vesicles of colorectal cancer and their influence on the pre-metastatic niche. Sci Rep. 2019;9:11177 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD81 Monoclonal Antibody (M38), PE

Catalog # :

A15781

Quantity :

100 tests

Price :

US 282

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Feline, Human, Rabbit

Applications :

Flow Cytometry: Assay Dependent

Species :

Feline, Human, Rabbit

Clone :

M38

Isotype :

IgG1

Storage :

4° C

Description :

CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.

Immunogen :

MOLT-4 (human T-ALL cell line)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent

Aliases :

26 kDa cell surface protein TAPA-1; CD 81 antigen; Cd81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CD81 molecule; CVID6; S5.7; Tapa1; Tapa-1; Target of the antiproliferative antibody 1; Tetraspanin28; tetraspanin-28; TSPAN28; Tspan-28