This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TRAIL-R2 (DR5) Monoclonal Antibody (DR-5-01-1), FITC
catalog :
A15750
quantity :
100 ug
price :
US 299.00
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
DR-5-01-1

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
citations: 2
Reference
Shi S, Xiu Y, Li Y, Yuan M, Shi K, Liu Q, et al. CD4+ T cells aggravate hemorrhagic brain injury. Sci Adv. 2023;9:eabq0712 pubmed publisher
Huang M, Yi C, Huang X, Yan J, Wei L, Tang W, et al. Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway. Oncol Lett. 2021;21:438 pubmed publisher
product information
Product Type :
Antibody
Product Name :
TRAIL-R2 (DR5) Monoclonal Antibody (DR-5-01-1), FITC
Catalog # :
A15750
Quantity :
100 ug
Price :
US 299.00
Clonality :
Monoclonal
Purity :
Size-exclusion chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1-5 ug/mL
Species :
Human
Clone :
DR-5-01-1
Isotype :
IgG1
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
Immunogen :
Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1-5 ug/mL
Aliases :
apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; Dr5; dr-5; Fas-like protein; KILLER; KILLER/DR5; KILLER/DR5 TRAIL death-inducing receptor; Ly98; MK; p53-regulated DNA damage-inducible cell death receptor(killer); sCD262; soluble CD262; TNF receptor superfamily member 10b; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL receptor 2; TRAILR2; TRAIL-R2; TRICK2; TRICK2A; TRICK2B; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; UNQ160/PRO186; ZTNFR9
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA