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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TCR beta Monoclonal Antibody (H57-597), PE
catalog :
A15408
quantity :
100 ug
price :
US 189.00
clonality :
monoclonal
host :
hamsters
conjugate :
PE
clone name :
H57-597
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 13
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 8e
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, et al. Sumoylation of RORĪ³t regulates TH17 differentiation and thymocyte development. Nat Commun. 2018;9:4870 pubmed publisher
  • flow cytometry; mouse; fig 1d
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Wei Y, Lu C, Chen J, Cui G, Wang L, Yu T, et al. High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice. Oncotarget. 2017;8:70-82 pubmed publisher
  • flow cytometry; mouse; fig 3
Mandal M, Marzouk A, Donnelly R, Ponzio N. Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells. Brain Behav Immun. 2011;25:863-71 pubmed publisher
  • flow cytometry; mouse; fig 2
Cawthon A, Alexander Miller M. Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity. J Immunol. 2002;169:3492-8 pubmed
  • flow cytometry; mouse; fig 3
Hayashi K, Natsume W, Watanabe T, Abe N, Iwai N, Okada H, et al. Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells. J Immunol. 2000;165:6816-24 pubmed
  • flow cytometry; mouse
Dejbakhsh Jones S, Strober S. Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow. Proc Natl Acad Sci U S A. 1999;96:14493-8 pubmed
  • flow cytometry; mouse
Ikawa T, Kawamoto H, Fujimoto S, Katsura Y. Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay. J Exp Med. 1999;190:1617-26 pubmed
  • flow cytometry; mouse
Ohmura K, Kawamoto H, Fujimoto S, Ozaki S, Nakao K, Katsura Y. Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse. J Immunol. 1999;163:4788-95 pubmed
  • flow cytometry; mouse
Kawamoto H, Ohmura K, Fujimoto S, Katsura Y. Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver. J Immunol. 1999;162:2725-31 pubmed
  • flow cytometry; mouse
Pear W, Aster J, Scott M, Hasserjian R, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 1996;183:2283-91 pubmed
  • flow cytometry; mouse
Ohteki T, MacDonald H. Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. J Exp Med. 1994;180:699-704 pubmed
  • flow cytometry; mouse
Ohteki T, Iwamoto M, Izui S, MacDonald H. Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur J Immunol. 1995;25:37-41 pubmed
product information
Product Type :
Antibody
Product Name :
TCR beta Monoclonal Antibody (H57-597), PE
Catalog # :
A15408
Quantity :
100 ug
Price :
US 189.00
Clonality :
Monoclonal
Purity :
purified
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.2 ug/1x10^6 cells
Species :
Mouse
Clone :
H57-597
Isotype :
IgG2
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Immunogen :
TCR affinity purified from mouse T cell hybridoma DO-11.101
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.2 ug/1x10^6 cells
Aliases :
bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA