product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD11b Monoclonal Antibody (M1/70), APC-Cyanine7
catalog :
A15390
quantity :
100 ug
price :
US 345.00
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
M1/70
reactivity :
human, mouse, rhesus macaque
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1n
Bhattacharjee O, Ayyangar U, Kurbet A, Lakshmanan V, Palakodeti D, Ginhoux F, et al. Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin. Front Immunol. 2021;12:718005 pubmed publisher
  • flow cytometry; mouse; 1 ug/ml; fig 2a
Borggrewe M, Kooistra S, Wesseling E, Gierschek F, Brummer M, Nowak E, et al. VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology. Acta Neuropathol Commun. 2021;9:91 pubmed publisher
  • flow cytometry; mouse; loading ...
Zhang Y, Liu J, Wang X, Zhang J, Xie C. Extracellular vesicle-encapsulated microRNA-23a from dorsal root ganglia neurons binds to A20 and promotes inflammatory macrophage polarization following peripheral nerve injury. Aging (Albany NY). 2021;13:6752-6764 pubmed publisher
  • flow cytometry; mouse; 1:10; loading ...; fig s3a
Kobayakawa K, Ohkawa Y, Yoshizaki S, Tamaru T, Saito T, Kijima K, et al. Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. Sci Adv. 2019;5:eaav5086 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1e
Lu D, Liao Y, Zhu S, Chen Q, Xie D, Liao J, et al. Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction. Stem Cell Res Ther. 2019;10:127 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 5c
Rosenzweig N, Dvir Szternfeld R, Tsitsou Kampeli A, Keren Shaul H, Ben Yehuda H, Weill Raynal P, et al. PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model. Nat Commun. 2019;10:465 pubmed publisher
  • flow cytometry; mouse; 1:300; loading ...; fig s7b
Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher
  • flow cytometry; mouse; 1:1000; loading ...; fig s3e
Tsiantoulas D, Sage A, Göderle L, Ozsvar Kozma M, Murphy D, Porsch F, et al. BAFF Neutralization Aggravates Atherosclerosis. Circulation. 2018;: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3a
Medaglia C, Giladi A, Stoler Barak L, De Giovanni M, Salame T, Biram A, et al. Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq. Science. 2017;358:1622-1626 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Mingay M, Chaturvedi A, Bilenky M, Cao Q, Jackson L, Hui T, et al. Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia. Leukemia. 2018;32:11-20 pubmed publisher
  • flow cytometry; mouse; fig 3
Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, et al. Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. Eur J Immunol. 2017;47:704-712 pubmed publisher
Wang D, Townsend L, DesOrmeaux G, Frangos S, Batchuluun B, Dumont L, et al. GDF15 promotes weight loss by enhancing energy expenditure in muscle. Nature. 2023;619:143-150 pubmed publisher
Wang S, Zhang Q, Lu D, Fang Y, Yan X, Chen J, et al. GPR84 regulates pulmonary inflammation by modulating neutrophil functions. Acta Pharmacol Sin. 2023;44:1665-1675 pubmed publisher
Ding Y, Gong P, Jiang J, Feng C, Li Y, Su X, et al. Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis. Cell Death Dis. 2022;13:996 pubmed publisher
Auyeung V, Downey M, Thamsen M, Wenger T, Backes B, Sheppard D, et al. IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2022;322:L564-L580 pubmed publisher
Wang Y, Wei B, Wang D, Wu J, Gao J, Zhong H, et al. DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis. Acta Pharm Sin B. 2022;12:262-273 pubmed publisher
Poillet Perez L, Sharp D, Yang Y, Laddha S, Ibrahim M, Bommareddy P, et al. Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nat Cancer. 2020;1:923-934 pubmed publisher
Agalave N, Mody P, Szabo Pardi T, Jeong H, Burton M. Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy. Front Immunol. 2021;12:642420 pubmed publisher
Agalave N, Lane B, Mody P, Szabo Pardi T, Burton M. Isolation, culture, and downstream characterization of primary microglia and astrocytes from adult rodent brain and spinal cord. J Neurosci Methods. 2020;340:108742 pubmed publisher
Poillet Perez L, Xie X, Zhan L, Yang Y, Sharp D, Hu Z, et al. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563:569-573 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD11b Monoclonal Antibody (M1/70), APC-Cyanine7
Catalog # :
A15390
Quantity :
100 ug
Price :
US 345.00
Clonality :
Monoclonal
Purity :
purified
Host :
Rat
Reactivity :
Baboon, Human, Mouse, Rabbit, Rhesus Monkey
Applications :
Flow Cytometry: 0.3 ug/1x10^6 cells
Species :
Baboon, Human, Mouse, Rabbit, Rhesus Monkey
Clone :
M1/70
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Immunogen :
C57BL/10 splenic T cells and concanavalin A stimulated C57BL/10 splenocytes.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.3 ug/1x10^6 cells
Aliases :
antigen CD11b (p170); antigen CD11b (p170); macrophage antigen alpha polypeptide; CD11 antigen-like family member B; CD11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component receptor 3 alpha-a; complement receptor type 3; CR3; CR-3 alpha chain; CR3A; F730045J24Rik; integrin alpha M; integrin alpha-M; integrin subunit alpha M; integrin, alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; leukocyte integrin alpha-M chain; LOC100351865; Ly-40; MAC1; Mac-1; Mac-1 alpha; Mac-1 alpha (Mac1A); MAC-1 alpha subunit; MAC1A; Mac-1a; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6; unnamed protein product
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA