CD45.2 Monoclonal Antibody (104), PE-Cyanine7 | Invitrogen A14736 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45.2 Monoclonal Antibody (104), PE-Cyanine7

catalog :

A14736

quantity :

25 µg

price :

US 89.75

clonality :

monoclonal

host :

mouse

conjugate :

PE/Cy7

clone name :

104

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:600; loading ...; fig 5a	Soncin I, Sheng J, Chen Q, Foo S, Duan K, Lum J, et al. The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. Nat Commun. 2018;9:582 pubmed publisher
flow cytometry; mouse; loading ...; fig s4c	Vo L, Kinney M, Liu X, Zhang Y, Barragan J, Sousa P, et al. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018;553:506-510 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD45.2 Monoclonal Antibody (104), PE-Cyanine7

Catalog # :

A14736

Quantity :

25 µg

Price :

US 89.75

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.3 µg/1x10^6 cells

Species :

Mouse

Clone :

104

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

CD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

Immunogen :

B10.S mouse thymocytes and splenocytes.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.3 µg/1x10^6 cells

Aliases :

B220; Cd45; CD45 antigen; CD45R; GP180; LCA; L-CA; leukocyte common antigen; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein

more info or order :

Invitrogen product webpage