NMDAR2B Polyclonal Antibody | Invitrogen A-6474 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NMDAR2B Polyclonal Antibody

catalog :

A-6474

quantity :

10µg

price :

US 459

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; 1:500; loading ...; fig 6a	Ampuero E, Jury N, Hartel S, Marzolo M, van Zundert B. Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons. J Cell Physiol. 2017;232:1187-1199 pubmed publisher
western blot; mouse; 1:500	Sceniak M, Lang M, Enomoto A, James Howell C, Hermes D, Katz D. Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice. Cereb Cortex. 2016;26:1938-1956 pubmed publisher
	Ma Q, Ying M, Sui X, Zhang H, Huang H, Yang L, et al. Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2Î± pathway in mice. J Alzheimers Dis. 2015;43:1413-27 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NMDAR2B Polyclonal Antibody

Catalog # :

A-6474

Quantity :

10µg

Price :

US 459

Clonality :

Polyclonal

Purity :

IgG fraction

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay Dependent, Immunofluorescence: 1:500-1:5000, Immunohistochemistry (Frozen): 1:500-1:5000, Immunoprecipitation: 3 µL, Western Blot: 1:100-1:500

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.

Immunogen :

Fusion protein containing amino acid residues 984–1104 of the C-terminal region of rat brain subunit 2B

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay Dependent, Immunofluorescence: 1:500-1:5000, Immunohistochemistry (Frozen): 1:500-1:5000, Immunoprecipitation: 3 µL, Western Blot: 1:100-1:500

Aliases :

AW490526; BOS_5813; EIEE27; GluN2B; GluRepsilon2; Glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; Grin2b; HGNC:4586; hNR 3; hNR3; MGC142178; MGC142180; MRD6; NMDAR2B; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3

more info or order :

Invitrogen product webpage