Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody (RC6F8)

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody (RC6F8)

catalog :

A-21328

quantity :

100µL

price :

US 444

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RC6F8

reactivity :

human, zebrafish

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:100; fig 4	Shehata M, Schnabl S, Demirtas D, Hilgarth M, Hubmann R, Ponath E, et al. Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia. Blood. 2010;116:2513-21 pubmed publisher
immunohistochemistry; zebrafish ; fig s2	Mapp O, Wanner S, Rohrschneider M, Prince V. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Dev Dyn. 2010;239:1596-608 pubmed publisher
	Morotti A, Panuzzo C, Crivellaro S, CarrÃ G, Fava C, Guerrasio A, et al. BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation. Cell Cycle. 2015;14:973-9 pubmed publisher
	Naslavsky N, Rahajeng J, Chenavas S, Sorgen P, Caplan S. EHD1 and Eps15 interact with phosphatidylinositols via their Eps15 homology domains. J Biol Chem. 2007;282:16612-22 pubmed
	Sendide K, Reiner N, Lee J, Bourgoin S, Talal A, Hmama Z. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1. J Immunol. 2005;174:4210-9 pubmed

product information

Product Type :

Antibody

Product Name :

Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody (RC6F8)

Catalog # :

A-21328

Quantity :

100µL

Price :

US 444

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Chemical

Applications :

Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent

Species :

Chemical

Clone :

RC6F8

Isotype :

IgM

Storage :

4° C

Description :

Phosphatidylinositol (3, 4, 5)-trisphosphate (PtdIns(3, 4, 5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol (4, 5)-bisphosphate. PtdIns (3, 4, 5) P3 is dephophosphorylated by the phosphatase, PTEN on the 3 position and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring. The PH domain in a number of proteins binds to PtdIns (3, 4, 5) P3. Such proteins include Akt/PKB, PDK1, Btk1 and ARNO. The generation of PtdIns (3, 4, 5) P3 at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins to translocate to the plasma membrane and accordingly affects their activity. The PH domain allows binding between PtdIns (3, 4, 5) P3 and G-protein coupled receptor kinases (GRKs). This enhances the binding of the GRK to the plasma membrane. [National Center for Biotechnology Information. PubChem Compound Database; CID=53477782].

Immunogen :

phosphatidylinositol 3,4,5-diphosphate

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent

Aliases :

C12H24O22P4; phosphatidylinositol 3; phosphatidylinositol-3; PIP3

more info or order :

Invitrogen product webpage