This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Nitrotyrosine Polyclonal Antibody
catalog :
A-21285
quantity :
500 uL
price :
US 465.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 32
Reference
Schwarcz S, Kov xe1 cs P, Kov xe1 cs T, Ujlaki G, Nyerges P, Uray K, et al. The pro- and antineoplastic effects of deoxycholic acid in pancreatic adenocarcinoma cell models. Mol Biol Rep. 2023;50:5273-5282 pubmed publisher
P xe9 rez Peir xf3 M, Valent xed Serra P, Le xf3 n Gonz xe1 lez B, Ampurdan xe9 s C, Duran X, Y xe9 lamos J, et al. Attenuation of Tumor Burden in Response to Rucaparib in Lung Adenocarcinoma: The Contribution of Oxidative Stress, Apoptosis, and DNA Damage. Int J Mol Sci. 2023;24: pubmed publisher
A A, W C, N N, L M, M D, Zhang D. α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease. Free Radic Biol Med. 2022;192:130-140 pubmed publisher
Adelusi O, Ramachandran A, Lemasters J, Jaeschke H. The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice. Toxicol Appl Pharmacol. 2022;445:116043 pubmed publisher
Catalani E, Fanelli G, Silvestri F, Cherubini A, Del Quondam S, Bongiorni S, et al. Nutraceutical Strategy to Counteract Eye Neurodegeneration and Oxidative Stress in Drosophila melanogaster Fed with High-Sugar Diet. Antioxidants (Basel). 2021;10: pubmed publisher
Mendoza Maga xf1 a M, Espinoza Guti xe9 rrez H, Nery Flores S, Ram xed rez Mendoza A, Cortez xc1 lvarez C, Bonnet Lemus R, et al. Curcumin Decreases Hippocampal Neurodegeneration and Nitro-Oxidative Damage to Plasma Proteins and Lipids Caused by Short-Term Exposure to Ozone. Molecules. 2021;26: pubmed publisher
Ogando D, Shyam R, Kim E, Wang Y, Liu C, Bonanno J. Inducible Slc4a11 Knockout Triggers Corneal Edema Through Perturbation of Corneal Endothelial Pump. Invest Ophthalmol Vis Sci. 2021;62:28 pubmed publisher
Jian Y, Liu Z, Wang H, Chen Y, Yin Y, Zhao Y, et al. Interplay of two transcription factors for recruitment of the chromatin remodeling complex modulates fungal nitrosative stress response. Nat Commun. 2021;12:2576 pubmed publisher
Kriss C, Duro N, Nadeau O, Guergues J, Chavez Chiang O, Culver Cochran A, et al. Site-specific identification and validation of hepatic histone nitration in vivo: Implications for alcohol-induced liver injury. J Mass Spectrom. 2021;56:e4713 pubmed publisher
Andrä M, Russ M, Jauk S, Lamacie M, Lang I, Arnold R, et al. Antioxidant Solution in Combination with Angiotensin-(1-7) Provides Myocardial Protection in Langendorff-Perfused Rat Hearts. Oxid Med Cell Longev. 2020;2020:2862631 pubmed publisher
Montecinos Oliva C, Arrázola M, Jara C, Tapia Rojas C, Inestrosa N. Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation. Pharmaceuticals (Basel). 2020;13: pubmed publisher
Duan L, Ramachandran A, Akakpo J, Woolbright B, Zhang Y, Jaeschke H. Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2020;387:114849 pubmed publisher
Hamaidia M, Gazon H, Hoyos C, Hoffmann G, Louis R, Duysinx B, et al. Inhibition of EZH2 methyltransferase decreases immunoediting of mesothelioma cells by autologous macrophages through a PD-1-dependent mechanism. JCI Insight. 2019;4: pubmed publisher
Russ M, Jauk S, Wintersteiger R, Andr xe4 M, Brcic I, Ortner A. Investigation of antioxidative effects of a cardioprotective solution in heart tissue. Mol Cell Biochem. 2019;461:73-80 pubmed publisher
Ramick M, Brian M, Matthews E, Patik J, Seals D, Lennon S, et al. Apocynin and Tempol ameliorate dietary sodium-induced declines in cutaneous microvascular function in salt-resistant humans. Am J Physiol Heart Circ Physiol. 2019;317:H97-H103 pubmed publisher
Lynch M, Tran M, Ralto K, Zsengellér Z, Raman V, Bhasin S, et al. TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance. JCI Insight. 2019;5: pubmed publisher
Chuang Y, Chen S, Hsu C, Chen S, Chen N, Jou S. Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway. Int J Mol Sci. 2019;20: pubmed publisher
Ryan F, Zarruk J, Lößlein L, David S. Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia. Front Neurosci. 2018;12:988 pubmed publisher
Xie P, Young M, Bian H, Niknam Bienia S, Hong S, Mustoe T, et al. Renal dysfunction aggravated impaired cutaneous wound healing in diabetic mice. Wound Repair Regen. 2019;27:49-58 pubmed publisher
Covarrubias A, Lecarpentier E, Lo A, Salahuddin S, Gray K, Karumanchi S, et al. AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts: Relevance for Preeclampsia Pathogenesis. Am J Pathol. 2019;189:104-114 pubmed publisher
Hubbard W, Harwood C, Geisler J, Vekaria H, Sullivan P. Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice. J Neurosci Res. 2018;96:1677-1688 pubmed publisher
Moya E, Arias P, Iturriaga R. Nitration of MnSOD in the Carotid Body and Adrenal Gland Induced by Chronic Intermittent Hypoxia. J Histochem Cytochem. 2018;66:753-765 pubmed publisher
Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, et al. Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells. EMBO Rep. 2017;18:2144-2159 pubmed publisher
Coll T, Chaufan G, Pérez Tito L, Ventureira M, Sobarzo C, Ríos de Molina M, et al. Oxidative stress and cellular and tissue damage in organogenic outbred mouse embryos after moderate perigestational alcohol intake. Mol Reprod Dev. 2017;84:1086-1099 pubmed publisher
Zhang W, Li H, Ogando D, Li S, Feng M, Price F, et al. Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium. EBioMedicine. 2017;16:292-301 pubmed publisher
Morgan B, Bates M, Rio R, Wang Z, Dopp J. Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia. Respir Physiol Neurobiol. 2016;234:47-59 pubmed publisher
Burke S, Zsengellér Z, Khankin E, Lo A, Rajakumar A, Dupont J, et al. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016;126:2561-74 pubmed publisher
Du K, Farhood A, Jaeschke H. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017;91:761-773 pubmed publisher
Moya E, Arias P, Varela C, Oyarce M, Del Rio R, Iturriaga R. Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation. Oxid Med Cell Longev. 2016;2016:9802136 pubmed publisher
Tapia Rojas C, Lindsay C, Montecinos Oliva C, Arrázola M, Retamales R, Bunout D, et al. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener. 2015;10:62 pubmed publisher
Chavali B, Masquelin T, Nilges M, Timm D, Stout S, Matter W, et al. ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments. Appl Magn Reson. 2015;46:853-873 pubmed
Hattori T, Sato Y, Kondo T, Ichinohashi Y, Sugiyama Y, Yamamoto M, et al. Administration of umbilical cord blood cells transiently decreased hypoxic-ischemic brain injury in neonatal rats. Dev Neurosci. 2015;37:95-104 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Nitrotyrosine Polyclonal Antibody
Catalog # :
A-21285
Quantity :
500 uL
Price :
US 465.00
Clonality :
Polyclonal
Purity :
purified
Host :
Rabbit
Reactivity :
Chemical
Applications :
Immunocytochemistry: Assay-dependent, Immunohistochemistry: 1:200-1:2,000, Western Blot: 1:200-1:2,000
Species :
Chemical
Isotype :
IgG
Storage :
4 C
Description :
Nitrotyrosine is a relatively stable product formed from various reaction pathways. Perhaps most notable is the reaction of peroxynitrite (formed from superoxide and nitric oxide (NO) radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins resulting in inactivation of certain housekeeping enzymes (e. g., alpha1-antiproteinase) as well as endogenous antioxidant enzymes such as catalase and superoxide dismutase (SOD). Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Nitrotyrosine has been implicated in the pathogenesis of several inflammatory, infectious, and degenerative human diseases, such as Alzheimer's and Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury. At the protein level, tyrosine nitration can lead to loss or alteration of protein function, as demonstrated for the oncogenic protein p53 and the mitochondrial protein, manganese-dependent superoxide dismutase (MnSOD).
Immunogen :
Keyhole limpet hemocyanin (KLH) containing nitrated tyrosines
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-dependent, Immunohistochemistry: 1:200-1:2,000, Western Blot: 1:200-1:2,000
Aliases :
Nitro-tyrosine
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA