c-Myc Monoclonal Antibody (289-19510) | Invitrogen A-21280 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

c-Myc Monoclonal Antibody (289-19510)

catalog :

A-21280

quantity :

100µL

price :

US 437

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

289-19510

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

citations: 20

Reference
Pereira C, Leal M, Abdelhay E, Demachki S, Assumpcao P, de Souza M, et al. MYC Amplification as a Predictive Factor of Complete Pathologic Response to Docetaxel-based Neoadjuvant Chemotherapy for Breast Cancer. Clin Breast Cancer. 2017;17:188-194 pubmed publisher
Hori A, Barnouin K, Snijders A, Toda T. A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. EMBO Rep. 2016;17:326-37 pubmed publisher
Lee C, Julian M, Tiller K, Meng F, DuConge S, Akter R, et al. Design and Optimization of Anti-amyloid Domain Antibodies Specific for Î²-Amyloid and Islet Amyloid Polypeptide. J Biol Chem. 2016;291:2858-73 pubmed publisher
Julian M, Lee C, Tiller K, Rabia L, Day E, Schick A, et al. Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies. Protein Eng Des Sel. 2015;28:339-50 pubmed publisher
Jha B, Gazestani V, Yip C, Salavati R. The DRBD13 RNA binding protein is involved in the insect-stage differentiation process of Trypanosoma brucei. FEBS Lett. 2015;589:1966-74 pubmed publisher
Ren J, Jin F, Yu Z, Zhao L, Wang L, Bai X, et al. MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. Tumour Biol. 2013;34:3945-58 pubmed publisher
Pereira C, Leal M, de Souza C, Montenegro R, Rey J, Carvalho A, et al. Prognostic and predictive significance of MYC and KRAS alterations in breast cancer from women treated with neoadjuvant chemotherapy. PLoS ONE. 2013;8:e60576 pubmed publisher
Zachariah R, Olson C, Ezeonwuka C, Rastegar M. Novel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes. PLoS ONE. 2012;7:e49763 pubmed publisher
Rastegar M, Hotta A, Pasceri P, Makarem M, Cheung A, Elliott S, et al. MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy. PLoS ONE. 2009;4:e6810 pubmed publisher
Qian M, Cai D, Verhey K, Tsai B. A lipid receptor sorts polyomavirus from the endolysosome to the endoplasmic reticulum to cause infection. PLoS Pathog. 2009;5:e1000465 pubmed publisher
Hasadsri L, Kreuter J, Hattori H, Iwasaki T, George J. Functional protein delivery into neurons using polymeric nanoparticles. J Biol Chem. 2009;284:6972-81 pubmed publisher
Deng Y, Singer R, Gu W. Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev. 2008;22:1037-50 pubmed publisher
Baumeister M, Martinu L, Rossman K, Sondek J, Lemmon M, Chou M. Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J Biol Chem. 2003;278:11457-64 pubmed
Hirsch J, Eslamizar L, Filanoski B, Malekzadeh N, Haugland R, Beechem J, et al. Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: uses for protein labeling, detection, and isolation. Anal Biochem. 2002;308:343-57 pubmed
Spoerl Z, Stumpf M, Noegel A, Hasse A. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. J Biol Chem. 2002;277:48858-67 pubmed
Xu X, Shi Y, Gao W, Mao G, Zhao G, Agrawal S, et al. The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. J Biol Chem. 2002;277:48913-22 pubmed
Hayes S, Chawla A, Corvera S. TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol. 2002;158:1239-49 pubmed
Le Stunff H, Galve Roperh I, Peterson C, Milstien S, Spiegel S. Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol. 2002;158:1039-49 pubmed
Klarlund J, Holik J, Chawla A, Park J, Buxton J, Czech M. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. J Biol Chem. 2001;276:40065-70 pubmed
Sato K, Sato M, Nakano A. Rer1p, a retrieval receptor for endoplasmic reticulum membrane proteins, is dynamically localized to the Golgi apparatus by coatomer. J Cell Biol. 2001;152:935-44 pubmed

product information

Product Type :

Antibody

Product Name :

c-Myc Monoclonal Antibody (289-19510)

Catalog # :

A-21280

Quantity :

100µL

Price :

US 437

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Tag

Applications :

Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Immunohistochemistry: 1-10 µg/mL

Species :

Tag

Clone :

289-19510

Isotype :

IgG1

Storage :

4° C

Description :

The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.

Immunogen :

Raised against the peptide AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA that corresponds to amino acids 408–439 of the human c-myc protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Immunohistochemistry: 1-10 µg/mL

Aliases :

AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; BHLHE39; c Myc; Class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog