HuR Monoclonal Antibody (19F12) | Invitrogen A-21277 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HuR Monoclonal Antibody (19F12)

catalog :

A-21277

quantity :

100 µg

price :

US 339.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

19F12

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:1250; loading ...; fig 5b	Blanco F, Preet R, Aguado A, Vishwakarma V, Stevens L, Vyas A, et al. Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. Oncotarget. 2016;7:74043-74058 pubmed publisher
immunocytochemistry; human; fig 5	Willett M, Pollard H, Vlasak M, Morley S. Localization of ribosomes and translation initiation factors to talin/beta3-integrin-enriched adhesion complexes in spreading and migrating mammalian cells. Biol Cell. 2010;102:265-76 pubmed publisher
western blot; human; 1:1000; fig 5	Trojanowicz B, Brodauf L, Sekulla C, Lorenz K, Finke R, Dralle H, et al. The role of AUF1 in thyroid carcinoma progression. Endocr Relat Cancer. 2009;16:857-71 pubmed publisher
immunohistochemistry - paraffin section; human; fig 1	Yi X, Zhou Y, Zheng W, Chambers S. HuR expression in the nucleus correlates with high histological grade and poor disease-free survival in ovarian cancer. Aust N Z J Obstet Gynaecol. 2009;49:93-8 pubmed publisher
immunohistochemistry - paraffin section; human; 1:1250 immunocytochemistry; human; 1:250	Young L, Sanduja S, Bemis Standoli K, PENA E, Price R, Dixon D. The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. Gastroenterology. 2009;136:1669-79 pubmed publisher
immunohistochemistry; human; fig 2 western blot; human; fig 6	Woo H, Zhou Y, Yi X, David C, Zheng W, Gilmore Hebert M, et al. Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer. Oncogene. 2009;28:1176-86 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 1 immunocytochemistry; mouse; 1:1000; fig 2 western blot; mouse; fig 3	Tiruchinapalli D, Caron M, Keene J. Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. J Neurochem. 2008;107:1529-43 pubmed publisher
immunoprecipitation; human; fig 8	Esnault S, Shen Z, Whitesel E, Malter J. The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes. J Immunol. 2006;177:6999-7006 pubmed
western blot; human	Shen Z, Esnault S, Malter J. The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils. Nat Immunol. 2005;6:1280-7 pubmed
immunocytochemistry; human immunoprecipitation; mouse; fig 6 western blot; mouse	Westmark C, Bartleson V, Malter J. RhoB mRNA is stabilized by HuR after UV light. Oncogene. 2005;24:502-11 pubmed
western blot; human; 1:10,000; fig 1	Sheflin L, Zou A, Spaulding S. Androgens regulate the binding of endogenous HuR to the AU-rich 3'UTRs of HIF-1alpha and EGF mRNA. Biochem Biophys Res Commun. 2004;322:644-51 pubmed
western blot; human; fig 7	Bergmann M, Staples K, Smith S, Barnes P, Newton R. Glucocorticoid inhibition of granulocyte macrophage-colony-stimulating factor from T cells is independent of control by nuclear factor-kappaB and conserved lymphokine element 0. Am J Respir Cell Mol Biol. 2004;30:555-63 pubmed
western blot; human; fig 6	Kullmann M, Göpfert U, Siewe B, Hengst L. ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev. 2002;16:3087-99 pubmed
	Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, et al. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018;20:285-295 pubmed publisher
	Peng W, Furuuchi N, Aslanukova L, Huang Y, Brown S, Jiang W, et al. Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development. Mol Cell Biol. 2018;38: pubmed publisher
	Hudy M, Proud D. Cigarette smoke enhances human rhinovirus-induced CXCL8 production via HuR-mediated mRNA stabilization in human airway epithelial cells. Respir Res. 2013;14:88 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HuR Monoclonal Antibody (19F12)

Catalog # :

A-21277

Quantity :

100 µg

Price :

US 339.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Western Blot: 1-5 µg/mL

Species :

Human

Clone :

19F12

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.

Immunogen :

Human HuR mRNA-binding protein.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1-5 µg/mL

Aliases :

2410055N02Rik; ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R); ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like 1; ELAV like RNA binding protein 1; ELAV like RNA binding protein 1a; ELAV1; Elavl1; elavl1 protein; elavl1a; elav-like generic protein; ELAV-like protein 1; ELAV-like protein 1; ELAV-like protein 1a; elav-related A; Elra; embryonic lethal, abnormal vision, drosophila, homolog-like 1; embryonic lethal, abnormal vision-related A; etID309757.2; fa25f08; fb59a02; fc60g02; Hu antigen R; Hua; HU-antigen A; hu-antigen R; Human antigen R; HuR; melG; ribonucleoprotein; W91709; wu:fa25f08; wu:fb59a02; wu:fc60g02; zHuA

more info or order :

Invitrogen product webpage