CD45 Monoclonal Antibody (30-F11), eVolve 655, eBioscience™ | Invitrogen 86-0451-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45 Monoclonal Antibody (30-F11), eVolve 655, eBioscience™

catalog :

86-0451-42

quantity :

100Tests

price :

US 301.00

clonality :

monoclonal

host :

rat

conjugate :

eVolve655

clone name :

30-F11

reactivity :

mouse

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

CD45 Monoclonal Antibody (30-F11), eVolve 655, eBioscience™

Catalog # :

86-0451-42

Quantity :

100Tests

Price :

US 301.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 5 µL/test

Species :

Mouse

Clone :

30-F11

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL/test

Aliases :

Cluster designation 45, common leukocyte antigen, T220 and B220