CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), Super Bright 780, eBioscience™ | Invitrogen 78-2799-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), Super Bright 780, eBioscience™

catalog :

78-2799-42

quantity :

100 Tests

price :

US 364

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

eBioJ105 (J105)

reactivity :

human, mouse, rhesus macaque

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1:25; loading ...; fig 1f	Stebegg M, Bignon A, Hill D, Silva Cayetano A, Krueger C, Vanderleyden I, et al. Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination. elife. 2020;9: pubmed publisher
flow cytometry; human; fig 1b flow cytometry; mouse; fig 6c	Lynn R, Weber E, Sotillo E, Gennert D, Xu P, Good Z, et al. c-Jun overexpression in CAR T cells induces exhaustion resistance. Nature. 2019;576:293-300 pubmed publisher
flow cytometry; human; loading ...; fig 6a	Asano T, Meguri Y, Yoshioka T, Kishi Y, Iwamoto M, Nakamura M, et al. PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy. Blood. 2017;129:2186-2197 pubmed publisher
	Lai C, Tseng P, Chen C, Satria R, Wang Y, Lin C. Different Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages. J Inflamm Res. 2021;14:5241-5249 pubmed publisher
	Rouers A, Chng M, Lee B, Rajapakse M, Kaur K, Toh Y, et al. Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection. Cell Rep Med. 2021;2:100278 pubmed publisher
	Singh Y, Trautwein C, Fendel R, Krickeberg N, Berezhnoy G, Bissinger R, et al. SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells. Heliyon. 2021;7:e07147 pubmed publisher
	Junker F, Gulati P, Wessels U, Seeber S, Stubenrauch K, Codarri Deak L, et al. A human receptor occupancy assay to measure anti-PD-1 binding in patients with prior anti-PD-1. Cytometry A. 2021;99:832-843 pubmed publisher
	Roberts A, Bentley L, Tang T, Stewart F, Pallini C, Juvvanapudi J, et al. Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation. Sci Rep. 2021;11:4030 pubmed publisher
	Bailur J, McCachren S, Pendleton K, Vasquez J, Lim H, Duffy A, et al. Risk-associated alterations in marrow T cells in pediatric leukemia. JCI Insight. 2020;5: pubmed publisher
	Wang Z, Zhao M, Yin J, Liu L, Hu L, Huang Y, et al. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases. J Clin Invest. 2020;130:3717-3733 pubmed publisher
	Brodska B, Otevrelova P, Salek C, Fuchs O, Gasova Z, Kuzelova K. High PD-L1 Expression Predicts for Worse Outcome of Leukemia Patients with Concomitant NPM1 and FLT3 Mutations. Int J Mol Sci. 2019;20: pubmed publisher
	Thaventhiran T, Alhumeed N, Yeang H, Sethu S, Downey J, Alghanem A, et al. Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist. MAbs. 2014;6:1290-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), Super Bright 780, eBioscience™

Catalog # :

78-2799-42

Quantity :

100 Tests

Price :

US 364

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Rhesus Monkey

Applications :

Flow Cytometry: 5 µL (0.5 µg)/test

Species :

Human, Rhesus Monkey

Clone :

eBioJ105 (J105)

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.5 µg)/test

Aliases :

CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; Protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2

more info or order :

Invitrogen product webpage