This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD8a Monoclonal Antibody (RPA-T8), Super Bright 780, eBioscience™
catalog :
78-0088-41
quantity :
25Tests
price :
US 163
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
RPA-T8
reactivity :
human
application :
flow cytometry
citations: 27
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 4a
Fenwick C, Loredo Varela J, Joo V, Pellaton C, Farina A, Rajah N, et al. Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway. J Exp Med. 2019;: pubmed publisher
  • flow cytometry; human; loading ...; fig 1a
Wang C, Edilova M, Wagar L, Mujib S, Singer M, Bernard N, et al. Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy. J Immunol. 2018;200:558-564 pubmed publisher
Pampusch M, Haran K, Hart G, Rakasz E, Rendahl A, Berger E, et al. Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations. Mol Ther Methods Clin Dev. 2020;16:1-10 pubmed publisher
Petrovic K, Robinson J, Whitworth K, Jinks E, Shaaban A, Lee S. TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo. PLoS ONE. 2019;14:e0224015 pubmed publisher
Mielke L, Liao Y, Clemens E, Firth M, Duckworth B, Huang Q, et al. TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis. J Exp Med. 2019;: pubmed publisher
Srivastava S, Salter A, Liggitt D, Yechan Gunja S, Sarvothama M, Cooper K, et al. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell. 2019;35:489-503.e8 pubmed publisher
Remmerswaal E, Hombrink P, Nota B, Pircher H, ten Berge I, van Lier R, et al. Expression of IL-7Rα and KLRG1 defines functionally distinct CD8+ T-cell populations in humans. Eur J Immunol. 2019;49:694-708 pubmed publisher
Hoang T, Harper J, Pino M, Wang H, Micci L, King C, et al. Bone Marrow-Derived CD4+ T Cells Are Depleted in Simian Immunodeficiency Virus-Infected Macaques and Contribute to the Size of the Replication-Competent Reservoir. J Virol. 2019;93: pubmed publisher
Chee J, Watson M, Chopra A, Nguyen B, Cook A, Creaney J, et al. Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors. BMC Res Notes. 2018;11:864 pubmed publisher
Petrelli A, Mijnheer G, Hoytema van Konijnenburg D, van der Wal M, Giovannone B, Mocholí E, et al. PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation. J Clin Invest. 2018;128:4669-4681 pubmed publisher
Qi Z, Zhang Q, Liu B, Shao H, Li C. Early Changes in Circulatory T Helper Type 1, 2, and 17 Cells of Patients with Out-of-Hospital Cardiac Arrest after Successful Cardiopulmonary Resuscitation. Chin Med J (Engl). 2018;131:2071-2079 pubmed publisher
Zhao X, Sankaran S, Yap J, Too C, Ho Z, Dolton G, et al. Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nat Commun. 2018;9:2716 pubmed publisher
Porichis F, Hart M, Massa A, Everett H, Morou A, Richard J, et al. Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells. J Immunol. 2018;201:971-981 pubmed publisher
Risnes L, Christophersen A, Dahal Koirala S, Neumann R, Sandve G, Sarna V, et al. Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease. J Clin Invest. 2018;128:2642-2650 pubmed publisher
Tedesco D, Thapa M, Chin C, Ge Y, Gong M, Li J, et al. Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease. Gastroenterology. 2018;154:2178-2193 pubmed publisher
Rivino L, Le Bert N, Gill U, Kunasegaran K, Cheng Y, Tan D, et al. Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation. J Clin Invest. 2018;128:668-681 pubmed publisher
Simons L, Ma K, de Chappedelaine C, Moiranghtem R, Elkaim E, Olivré J, et al. Generation of adult human T-cell progenitors for immunotherapeutic applications. J Allergy Clin Immunol. 2018;141:1491-1494.e4 pubmed publisher
Schulten V, Tripple V, Seumois G, Qian Y, Scheuermann R, Fu Z, et al. Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol. 2018;141:775-777.e6 pubmed publisher
Sauermann U, Radaelli A, Stolte Leeb N, Raue K, Bissa M, Zanotto C, et al. Vector Order Determines Protection against Pathogenic Simian Immunodeficiency Virus Infection in a Triple-Component Vaccine by Balancing CD4+ and CD8+ T-Cell Responses. J Virol. 2017;91: pubmed publisher
Hong J, Silveira E, Amancha P, Byrareddy S, Gumber S, Chang K, et al. Early initiation of antiretroviral treatment postSIV infection does not resolve lymphoid tissue activation. AIDS. 2017;31:1819-1824 pubmed publisher
Swan Z, Bouwer A, Wonderlich E, Barratt Boyes S. Persistent accumulation of gut macrophages with impaired phagocytic function correlates with SIV disease progression in macaques. Eur J Immunol. 2017;47:1925-1935 pubmed publisher
Miller S, Miles B, Guo K, Folkvord J, Meditz A, McCarter M, et al. Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1. J Virol. 2017;91: pubmed publisher
Murray S, Nesterenko P, Vanarsdall A, Munks M, Smart S, Veziroglu E, et al. Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans. J Exp Med. 2017;214:1889-1899 pubmed publisher
Costa N, Marques O, Godinho S, Carvalho C, Leal B, Figueiredo A, et al. Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives. Clin Exp Immunol. 2017;189:318-330 pubmed publisher
Nouri Shirazi M, Bible B, Zeng M, Tamjidi S, Bossart G. Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care. BMC Vet Res. 2017;13:78 pubmed publisher
Restorick S, Durant L, Kalra S, Hassan Smith G, Rathbone E, Douglas M, et al. CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells. Brain Behav Immun. 2017;64:71-79 pubmed publisher
Weinacht K, Charbonnier L, Alroqi F, Plant A, Qiao Q, Wu H, et al. Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. J Allergy Clin Immunol. 2017;139:1629-1640.e2 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD8a Monoclonal Antibody (RPA-T8), Super Bright 780, eBioscience™
Catalog # :
78-0088-41
Quantity :
25Tests
Price :
US 163
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.06 µg)/test
Species :
Human
Clone :
RPA-T8
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.06 µg)/test
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA