product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (GK1.5), Super Bright 780, eBioscience
catalog :
78-0041-82
quantity :
100 µg
price :
US 354
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
GK1.5
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 36
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s8d
Wang Z, He L, Li W, Xu C, Zhang J, Wang D, et al. GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma. J Immunother Cancer. 2021;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3
Flamini S, Sergeev P, Viana de Barros Z, Mello T, Biagioli M, Paglialunga M, et al. Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment. Cell Death Dis. 2021;12:421 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Datta M, Staszewski O. Hdac1 and Hdac2 are essential for physiological maturation of a Cx3cr1 expressing subset of T-lymphocytes. BMC Res Notes. 2021;14:135 pubmed publisher
  • flow cytometry; mouse
Chu A, Kok S, TSUI J, Lin M, Aguirre B, Wadehra M. Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface. J Reprod Immunol. 2021;145:103309 pubmed publisher
  • flow cytometry; mouse; fig 1
Khan T, Hartley A, Haskard D, Caga Anan M, Pennell D, Collins P, et al. Oxidised LDL and Anti-Oxidised LDL Antibodies Are Reduced by Lipoprotein Apheresis in a Randomised Controlled Trial on Patients with Refractory Angina and Elevated Lipoprotein(a). Antioxidants (Basel). 2021;10: pubmed publisher
  • flow cytometry; mouse; fig 1
Herring S, Oda J, Wagoner J, Kirchmeier D, O Connor A, Nelson E, et al. Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs. Antimicrob Agents Chemother. 2021;65: pubmed publisher
  • flow cytometry; mouse; fig 1
Mazur Bialy A, Pochec E. The Time-Course of Antioxidant Irisin Activity: Role of the Nrf2/HO-1/HMGB1 Axis. Antioxidants (Basel). 2021;10: pubmed publisher
  • flow cytometry; mouse; fig 1
Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher
  • flow cytometry; mouse; fig 1c
Zhao L, Hu S, Davila M, Yang J, Lin Y, Albanese J, et al. Coordinated co-migration of CCR10+ antibody-producing B cells with helper T cells for colonic homeostatic regulation. Mucosal Immunol. 2021;14:420-430 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4
Neuper T, Neureiter D, Sarajlic M, Strandt H, Bauer R, Schwarz H, et al. IL-31 transgenic mice show reduced allergen-induced lung inflammation. Eur J Immunol. 2021;51:191-196 pubmed publisher
  • flow cytometry; mouse; fig 1
Jin C, Du L, Nuerlan A, Wang X, Yang Y, Guo R. High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma. Aging (Albany NY). 2020;13:3518-3535 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4e
Luoni M, Giannelli S, Indrigo M, Niro A, Massimino L, Iannielli A, et al. Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Witalis M, Chang J, Zhong M, Bouklouch Y, Panneton V, Li J, et al. Progression of AITL-like tumors in mice is driven by Tfh signature proteins and T-B cross talk. Blood Adv. 2020;4:868-879 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 3b
Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, et al. Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019;10:2352 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Lin Y, Wang L, Lee C, Chen S. Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses. Sci Rep. 2018;8:12184 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Cheng Y, Zhu X, Wang X, Zhuang Q, Huyan X, Sun X, et al. Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation. Front Immunol. 2018;9:1566 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Safya H, Mellouk A, Legrand J, Le Gall S, Benbijja M, Kanellopoulos Langevin C, et al. Variations in Cellular Responses of Mouse T Cells to Adenosine-5'-Triphosphate Stimulation Do Not Depend on P2X7 Receptor Expression Levels but on Their Activation and Differentiation Stage. Front Immunol. 2018;9:360 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
A Verghese D, Demir M, Chun N, Fribourg M, Cravedi P, Llaudó I, et al. T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival. J Immunol. 2018;200:2186-2198 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Liang W, Mao S, Sun S, Li M, Li Z, Yu R, et al. Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation. Front Immunol. 2018;9:78 pubmed publisher
Sato S, Shimizu E, He J, Ogawa M, Asai K, Yazu H, et al. Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease. Int J Mol Sci. 2021;22: pubmed publisher
Steinbuck M, Seenappa L, Jakubowski A, McNeil L, Haqq C, Demuth P. A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2. Sci Adv. 2021;7: pubmed publisher
Yuan B, Clark C, Wu B, Yang J, Drerup J, Li T, et al. Estrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch. J Immunother Cancer. 2021;9: pubmed publisher
Song Y, Wang Z, Jiang J, Piao Y, Li L, Xu C, et al. DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma. J Cell Mol Med. 2020;24:13739-13750 pubmed publisher
Wu B, Chiang H, Sun X, Yuan B, Mitra P, Hu Y, et al. Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation. J Immunother Cancer. 2020;8: pubmed publisher
Pierini S, Tanyi J, Simpkins F, George E, Uribe Herranz M, Drapkin R, et al. Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target. JCI Insight. 2020;5: pubmed publisher
Xue F, Yu M, Li L, Zhang W, Ma Y, Dong L, et al. Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma. Int J Biol Sci. 2020;16:2072-2083 pubmed publisher
Kim Y, Park S, Ha H, Lee A, Won H, Cha H, et al. HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment. J Cancer. 2020;11:4059-4072 pubmed publisher
Waaler J, Mygland L, Tveita A, Strand M, Solberg N, Olsen P, et al. Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020;3:196 pubmed publisher
Wilkinson A, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo R, et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature. 2019;: pubmed publisher
Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown D, Hanke Gogokhia C, et al. Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell Host Microbe. 2019;25:285-299.e8 pubmed publisher
McCall C, Zabalawi M, Liu T, Martin A, Long D, Buechler N, et al. Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival. JCI Insight. 2018;3: pubmed publisher
Müller Graff F, Fitzner B, Jaster R, Vollmar B, Zechner D. Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells. World J Gastroenterol. 2018;24:3120-3129 pubmed publisher
Massengale M, Wagers A, Vogel H, Weissman I. Hematopoietic cells maintain hematopoietic fates upon entering the brain. J Exp Med. 2005;201:1579-89 pubmed
Rifa i M, Kawamoto Y, Nakashima I, Suzuki H. Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. J Exp Med. 2004;200:1123-34 pubmed
Herman A, Freeman G, Mathis D, Benoist C. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med. 2004;199:1479-89 pubmed
Xu H, Wipasa J, Yan H, Zeng M, Makobongo M, Finkelman F, et al. The mechanism and significance of deletion of parasite-specific CD4(+) T cells in malaria infection. J Exp Med. 2002;195:881-92 pubmed
product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (GK1.5), Super Bright 780, eBioscience
Catalog # :
78-0041-82
Quantity :
100 µg
Price :
US 354
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
GK1.5
Isotype :
IgG2b, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA