ZO-1 Recombinant Mouse Monoclonal Antibody (ZO1-1A12) | Invitrogen 740002M20UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZO-1 Recombinant Mouse Monoclonal Antibody (ZO1-1A12)

catalog :

740002M20UG

quantity :

20 uL

price :

US 208.00

clonality :

recombinant

host :

mouse

conjugate :

nonconjugated

clone name :

ZO1-1A12

reactivity :

human, mouse, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

ZO-1 Recombinant Mouse Monoclonal Antibody (ZO1-1A12)

Catalog # :

740002M20UG

Quantity :

20 uL

Price :

US 208.00

Clonality :

Recombinant Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Non-human primate

Applications :

Flow Cytometry: 0.063 ug/test, Immunocytochemistry: 1:1,000-1:2,000, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:5,000

Species :

Canine, Human, Mouse, Non-human primate

Clone :

ZO1-1A12

Isotype :

IgG1, kappa

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.

Immunogen :

Human recombinant ZO-1 fusion protein encompassing amino acids 334-634

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.063 ug/test, Immunocytochemistry: 1:1,000-1:2,000, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:5,000

Aliases :

DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1