LNX1 Polyclonal Antibody | Invitrogen 720003 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LNX1 Polyclonal Antibody

catalog :

720003

quantity :

100 ug

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

LNX1 Polyclonal Antibody

Catalog # :

720003

Quantity :

100 ug

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 3-4 ug/mL, Western Blot: 2-3 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is known as PDZRN2 (PDZ domain-containing RING finger 2). It is through its RING finger and PDZ domains that Lnx1 forms oligomers and interacts with some of its target proteins such as JAM4 to form multiprotein complexes. Lnx1 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Phosphotyrosine binding domain (PTB) on Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus positively regulates the Notch signaling pathway.

Immunogen :

Multiple peptides against Human LNX1 (aa 200-213, 704-719)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 3-4 ug/mL, Western Blot: 2-3 ug/mL

Aliases :

E3 ubiquitin-protein ligase LNX; Ligand of Numb protein X 1; ligand of Numb-binding protein 1; Ligand of Numb-protein X 1; ligand of numb-protein X 1, E3 ubiquitin protein ligase; LNX; Lnx1; MPDZ; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; numb-binding protein 1; PDZ domain-containing RING finger protein 2; PDZRN2; RING-type E3 ubiquitin transferase LNX; UNQ574/PRO1136