MBD1 Recombinant Superclonal Antibody (12HCLC) | Invitrogen 712384 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MBD1 Recombinant Superclonal Antibody (12HCLC)

catalog :

712384

quantity :

100 ug

price :

US 500.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

12HCLC

reactivity :

human

application :

immunocytochemistry

product information

Product Type :

Antibody

Product Name :

MBD1 Recombinant Superclonal Antibody (12HCLC)

Catalog # :

712384

Quantity :

100 ug

Price :

US 500.00

Clonality :

Recombinant Superclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ChIP Assay: 2 ug/million cells, Immunocytochemistry: 1:100

Species :

Human

Clone :

12HCLC

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

Immunogen :

Protein corresponding to human MBD1 [aa400-aa605]

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 2 ug/million cells, Immunocytochemistry: 1:100

Aliases :

CXXC3; CXXC-type zinc finger protein 3; Mbd1; methyl-CpG binding domain protein 1; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1; Protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription