Arginase 1 Recombinant Superclonal Antibody (24HCLC) | Invitrogen 711765 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Arginase 1 Recombinant Superclonal Antibody (24HCLC)

catalog :

711765

quantity :

100 ug

price :

US 520.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

24HCLC

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 2

Reference
Hansen L, Yang R, Roso K, Wang W, Chen L, Yang Q, et al. MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization. Sci Rep. 2022;12:4183 pubmed publisher
Zhai G, Qie S, Guo Q, Qi Y, Zhou Y. sDR5-Fc inhibits macrophage M1 polarization by blocking the glycolysis. J Geriatr Cardiol. 2021;18:271-280 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Arginase 1 Recombinant Superclonal Antibody (24HCLC)

Catalog # :

711765

Quantity :

100 ug

Price :

US 520.00

Clonality :

Recombinant Superclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 5 ug/mL, Western Blot: 2.5 ug/mL

Species :

Human, Mouse

Clone :

24HCLC

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Immunogen :

Peptides corresponding to human Arginase 1 [1) aa304-aa322 2) aa52-aa71]

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 ug/mL, Western Blot: 2.5 ug/mL

Aliases :

AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase