Phospho-c-Abl (Tyr393) Recombinant Superclonal Antibody (19HCLC)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-c-Abl (Tyr393) Recombinant Superclonal Antibody (19HCLC)

catalog :

711366

quantity :

100 ug

price :

US 414.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

19HCLC

The same clone is also sold as:

Abcam: ab277782

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry

citations: 1

Reference
Moro A, Driscoll T, Boraas L, Armero W, Kasper D, Baeyens N, et al. MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis. Nat Cell Biol. 2019;21:348-358 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-c-Abl (Tyr393) Recombinant Superclonal Antibody (19HCLC)

Catalog # :

711366

Quantity :

100 ug

Price :

US 414.00

Clonality :

Recombinant Superclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 5 ug/1x10^6 cells, Immunocytochemistry: 2 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse, Rat

Clone :

19HCLC

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.

Immunogen :

Peptide corresponding to Human ABL1 (aa 390-397)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 ug/1x10^6 cells, Immunocytochemistry: 2 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl; Abl 1 antib; ABL proto-oncogene 1, non-receptor tyrosine kinase; Abl1; ABL2; ABLL; AI325092; ARG; B30; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-ABL1; E430008G22Rik; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1