BDNF Recombinant Polyclonal Antibody (19HCLC) | Invitrogen 710306 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BDNF Recombinant Polyclonal Antibody (19HCLC)

catalog :

710306

quantity :

100 µg

price :

US 450.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

19HCLC

reactivity :

human, mouse

application :

western blot

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 5	Huang Y, Lin C, Liao H, Liu C, Chen Y, Chiu W, et al. Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 2016;328:201-9 pubmed publisher
	Ke X, Huang Y, Fu Q, Lane R, Majnik A. Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus. Dev Neurosci. 2021;43:95-105 pubmed publisher
	Kim A, Jung H, Kim Y, Kim S, Park J, Lee S, et al. The Knockdown of TREK-1 in Hippocampal Neurons Attenuate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. Int J Mol Sci. 2019;20: pubmed publisher
	Sosanya N, Garza T, Stacey W, Crimmins S, Christy R, Cheppudira B. Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain. BMC Neurosci. 2019;20:17 pubmed publisher
	Caserta M, Ben Soussan T, Vetriani V, Venditti S, Verdone L. Influence of Quadrato Motor Training on Salivary proNGF and proBDNF. Front Neurosci. 2019;13:58 pubmed publisher
	Moro A, Driscoll T, Boraas L, Armero W, Kasper D, Baeyens N, et al. MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis. Nat Cell Biol. 2019;21:348-358 pubmed publisher

product information

Product Type :

Antibody

Product Name :

BDNF Recombinant Polyclonal Antibody (19HCLC)

Catalog # :

710306

Quantity :

100 µg

Price :

US 450.00

Clonality :

Recombinant Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: 1-3 µg/mL

Species :

Human, Mouse

Clone :

19HCLC

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.

Immunogen :

Recombinant protein corresponding to amino acids 129–247 of human BDNF

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1-3 µg/mL

Aliases :

abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF

more info or order :

Invitrogen product webpage