INSR beta Recombinant Superclonal Antibody (6HCLC) | Invitrogen 710076 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

INSR beta Recombinant Superclonal Antibody (6HCLC)

catalog :

710076

quantity :

100 ug

price :

US 496.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

6HCLC

reactivity :

human

application :

western blot

citations: 1

Reference
Hering H, Zoschke C, Kühn M, Gadicherla A, Weindl G, Luch A, et al. TatS: a novel in vitro tattooed human skin model for improved pigment toxicology research. Arch Toxicol. 2020;94:2423-2434 pubmed publisher

product information

Product Type :

Antibody

Product Name :

INSR beta Recombinant Superclonal Antibody (6HCLC)

Catalog # :

710076

Quantity :

100 ug

Price :

US 496.00

Clonality :

Recombinant Superclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 2-5 ug/mL

Species :

Human

Clone :

6HCLC

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

Immunogen :

Recombinant protein corresponding to amino acids 1283–1382 of human IR beta subunit

Format :

Liquid

Applications w/Dilutions :

Western Blot: 2-5 ug/mL

Aliases :

4932439J01Rik; CD220; CD220 beta; CD221; D630014A15Rik; HHF5; IGF-I receptor; Insr; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR beta; IR-A; IR-B