BMP-2 Recombinant Superclonal Antibody (18HCLC) | Invitrogen 710022 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BMP-2 Recombinant Superclonal Antibody (18HCLC)

catalog :

710022

quantity :

100 ug

price :

US 450.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

BMP

clone name :

18HCLC

reactivity :

human

application :

western blot, immunocytochemistry

citations: 2

Reference
Chen J, Lin Y, Sun Z. Inhibition of miR-101-3p prevents human aortic valve interstitial cell calcification through regulation of CDH11/SOX9 expression. Mol Med. 2023;29:24 pubmed publisher
Carracedo M, Pawelzik S, Artiach G, Pouwer M, Plunde O, Saliba Gustafsson P, et al. The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis. Br J Pharmacol. 2022;179:4709-4721 pubmed publisher

product information

Product Type :

Antibody

Product Name :

BMP-2 Recombinant Superclonal Antibody (18HCLC)

Catalog # :

710022

Quantity :

100 ug

Price :

US 450.00

Clonality :

Recombinant Superclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1 ug/mL, Western Blot: 4-5 ug/mL

Species :

Human

Clone :

18HCLC

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).

Immunogen :

Protein corresponding to amino acids 283-396 of human BMP2

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1 ug/mL, Western Blot: 4-5 ug/mL

Aliases :

2610024H22Rik; AI467020; AL117858; AW546137; BB189135; BDA2; BMP; BMP2; BMP-2; BMP2A; BMP-2A; BMPRII; BMPR-II; Bone morphogenetic; Bone morphogenetic protein; Bone morphogenetic protein 2; bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A); bone morphogenetic protein 2A; H-BMP-2; morphogen