IRS1 Recombinant Polyclonal Antibody (21HCLC) | Invitrogen 710009 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IRS1 Recombinant Polyclonal Antibody (21HCLC)

catalog :

710009

quantity :

100 µg

price :

US 480.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

21HCLC

reactivity :

human

application :

western blot

citations: 1

Reference
Yu W, Singh R, Wang Z, O Malley B, Yi P. The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1. J Biol Chem. 2021;296:100739 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IRS1 Recombinant Polyclonal Antibody (21HCLC)

Catalog # :

710009

Quantity :

100 µg

Price :

US 480.00

Clonality :

Recombinant Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 4-5 µg/mL

Species :

Human

Clone :

21HCLC

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.

Immunogen :

Recombinant protein corresponding to amino acids 694-875.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 4-5 µg/mL

Aliases :

G972R; HIRS-1; Insulin receptor substrate 1; IRS1; IRS-1; IRS1IRM; pp185