NMDAR2B Polyclonal Antibody | Invitrogen 71-8600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NMDAR2B Polyclonal Antibody

catalog :

71-8600

quantity :

100 µg

price :

US 430.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:300; loading ...; fig 3	Dong Y, Hsu F, Koziol White C, Stepanova V, Jude J, Gritsiuta A, et al. Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells. Sci Rep. 2021;11:8205 pubmed publisher
western blot; mouse; 1:250; loading ...; fig 3a	Haubrich J, Bernabo M, Nader K. Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation. elife. 2020;9: pubmed publisher
western blot; mouse; 1:3000; fig 4	Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
blocking or activating experiments; rat; fig s2	WÃ¼rdemann T, Kersten M, Tokay T, Guli X, Kober M, Rohde M, et al. Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function. Brain Res. 2016;1633:10-18 pubmed publisher
	Iemolo A, De Risi M, Giordano N, Torromino G, Somma C, Cavezza D, et al. Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy. NPJ Parkinsons Dis. 2023;9:92 pubmed publisher
	Ferrari E, Scheggia D, Zianni E, Italia M, Brumana M, Palazzolo L, et al. Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson's disease. Pharmacol Res. 2022;183:106375 pubmed publisher
	Franchini L, Stanic J, Ponzoni L, Mellone M, Carrano N, Musardo S, et al. Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition. iScience. 2019;19:927-939 pubmed publisher
	McKay S, Ryan T, McQueen J, Indersmitten T, Marwick K, Hasel P, et al. The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences. Cell Rep. 2018;25:841-851.e4 pubmed publisher
	Guo Y, Zhang W, Chen X, Fu J, Cheng W, Song D, et al. Timing-dependent LTP and LTD in mouse primary visual cortex following different visual deprivation models. PLoS ONE. 2017;12:e0176603 pubmed publisher
	Megill A, Tran T, Eldred K, Lee N, Wong P, HOE H, et al. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:11346-57 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NMDAR2B Polyclonal Antibody

Catalog # :

71-8600

Quantity :

100 µg

Price :

US 430.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Rabbit, Rat

Applications :

Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Species :

Rabbit, Rat

Isotype :

IgG

Storage :

-20°C

Description :

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.

Immunogen :

Fusion protein including a 251 amino acid sequence from the N-terminal portion of the rat NMDAR 2B protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Aliases :

AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3

more info or order :

Invitrogen product webpage