c-Met Polyclonal Antibody | Invitrogen 71-8000 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

c-Met Polyclonal Antibody

catalog :

71-8000

quantity :

100 µg

price :

US 500.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, other

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
other; human; 1:800; fig s3 immunohistochemistry - paraffin section; human; 1:200; fig s4 immunocytochemistry; human; 1:1000; fig s2 western blot; human; 1:1000; fig s1	De Herdt M, Willems S, van der Steen B, Noorlag R, Verhoef E, van Leenders G, et al. Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma. Oncotarget. 2016;7:13167-81 pubmed publisher
	Zhou Y, Cui G, Xu H, Chun J, Yang D, Zhang Z, et al. Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis. Cell Death Dis. 2023;14:476 pubmed publisher
	Fernandes M, Hoggard B, Jamme P, Paget S, Truong M, Gr xe9 goire V, et al. MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanised HGF knock-in mice. Mol Oncol. 2023;: pubmed publisher
	Hara T, Kimura A, Miyazaki T, Tanaka H, Morimoto M, Nakai K, et al. Cabozantinib inhibits AXL- and MET-dependent cancer cell migration induced by growth-arrest-specific 6 and hepatocyte growth factor. Biochem Biophys Rep. 2020;21:100726 pubmed publisher
	Wang P, Song X, Cao D, Cui K, Wang J, Utpatel K, et al. Oncogene-dependent function of BRG1 in hepatocarcinogenesis. Cell Death Dis. 2020;11:91 pubmed publisher
	Matte I, Lane D, Laplante C, Garde Granger P, Rancourt C, PichÃ© A. Ovarian cancer ascites enhance the migration of patient-derived peritoneal mesothelial cells via cMet pathway through HGF-dependent and -independent mechanisms. Int J Cancer. 2015;137:289-98 pubmed publisher

product information

Product Type :

Antibody

Product Name :

c-Met Polyclonal Antibody

Catalog # :

71-8000

Quantity :

100 µg

Price :

US 500.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: Assay-dependent

Species :

Human

Isotype :

IgG

Storage :

-20°C

Description :

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

Immunogen :

Synthetic peptide derived from the C-terminal or the human c-Met protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: Assay-dependent

Aliases :

AI838057; AUTS9; bHLHe59; CG1705; CG1705-PA; CG1705-PB; cmet; c-met; c-met proto-oncogene; c-Met receptor tyrosine kinase; c-Met/HGF receptor; D249; DFNB97; Dmel CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; HGFR; HGF-SF receptor; juvenile hormone resistance; met; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; Met; protein tyrosin kinase; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; scatter factor receptor; SF receptor; soluble c met; tyrosine-protein kinase Met

more info or order :

Invitrogen product webpage