CDH11 Polyclonal Antibody | Invitrogen 71-7600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CDH11 Polyclonal Antibody

catalog :

71-7600

quantity :

100 ug

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 4	Kourtidis A, Anastasiadis P. PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications. Cell Cycle. 2016;15:498-505 pubmed publisher
	Liu Y, Lei P, Samuel R, Kashyap A, Groth T, Bshara W, et al. Cadherin-11 increases tumor cell proliferation and metastatic potential via Wnt pathway activation. Mol Oncol. 2023;17:2056-2073 pubmed publisher
	Li Z, Lin Z, Liu S, Yagi H, Zhang X, Yocum L, et al. Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing. Adv Sci (Weinh). 2022;9:e2105909 pubmed publisher
	Passanha F, Geuens T, LaPointe V. Cadherin-11 influences differentiation in human mesenchymal stem cells by regulating the extracellular matrix via the TGFβ1 pathway. Stem Cells. 2022;: pubmed publisher
	Payne S, Ram P, Srinivasan D, Le T, Levin M, Oudin M. Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. EBioMedicine. 2022;75:103767 pubmed publisher
	Johnson C, Merryman W. Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11. J Biomech. 2021;119:110253 pubmed publisher
	Chakrabarti S, Hore Z, Pattison L, Lalnunhlimi S, Bhebhe C, Callejo G, et al. Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain. Pain. 2020;161:2129-2141 pubmed publisher
	Satriyo P, Bamodu O, Chen J, Aryandono T, Haryana S, Yeh C, et al. Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer. J Clin Med. 2019;8: pubmed publisher
	Domke L, Franke W. The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system. Cell Tissue Res. 2019;375:451-482 pubmed publisher
	Tome Garcia J, Erfani P, Nudelman G, Tsankov A, Katsyv I, Tejero R, et al. Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Nat Commun. 2018;9:4020 pubmed publisher
	Dekker S, van Geemen D, van den Bogaerdt A, Driessen Mol A, Aikawa E, Smits A. Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves. Front Cardiovasc Med. 2018;5:105 pubmed publisher
	King R, Li Y, Wang J, Struebing F, Geisert E. Genomic Locus Modulating IOP in the BXD RI Mouse Strains. G3 (Bethesda). 2018;8:1571-1578 pubmed publisher
	Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard O Riley R, Wilson T, et al. Fibrosis and hypoxia-inducible factor-1Î±-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors. Am J Pathol. 2015;185:3090-101 pubmed publisher
	Noss E, Watts G, Zocco D, Keller T, Whitman M, Blobel C, et al. Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism. Arthritis Res Ther. 2015;17:126 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CDH11 Polyclonal Antibody

Catalog # :

71-7600

Quantity :

100 ug

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 2 ug/mL, Immunohistochemistry: Assay-dependent, Western Blot: 1-2 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C

Description :

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains. Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups. Type I cadherins, including cadherins E (epithelial), N (neural), P (placental), and R (retinal) cadherin differ from type I cadherins in their specific amino acid sequences. Type II cadherins include human cadherin-5, -6, -8, -11, and -12. Type II cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin-11 (OB-Cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of Cadherin-11 has been noted in brain, spinal cord, bone marrow and bone cells, and is regulated in human endometrial glandular epithelial and stromal cells. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. A variant Cadherin-11 gene (variant form) encodes a truncated protein with an unusual cytoplasmic domain not present in other cadherins. The variant protein is generated by alternative splicing, utilizing a 179 bp intronic sequence. Recently, Cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested but not in non-invasive cell lines, suggesting that Cadherin-11 may be a marker for aggressive, invasive tumor subsets.

Immunogen :

Recombinant protein derived from the intracellular domain of the human Cadherin 11 protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 2 ug/mL, Immunohistochemistry: Assay-dependent, Western Blot: 1-2 ug/mL

Aliases :

CAD11; Cad-11; Cadherin; cadherin 11; cadherin 11, type 2, OB-cadherin (osteoblast); cadherin-11; Cdh11; CDHOB; OB; OB Cadherin; OB-cadherin; OSF-4; Osteoblast cadherin; osteoblast-cadherin

more info or order :

Invitrogen product webpage