product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PAX2 Polyclonal Antibody
catalog :
71-6000
quantity :
100 µg
price :
US 450.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
cane toad, little skate, human, mouse, rat, zebrafish , domestic sheep
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 93
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:400; loading ...; fig 3c
Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, et al. Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development. 2021;148: pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig s2d
Fukunaga I, Oe Y, Chen C, Danzaki K, Ohta S, Koike A, et al. Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells. Front Cell Dev Biol. 2021;9:602197 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 6c
Russo A, Colina J, Moy J, Baligod S, Czarnecki A, Varughese P, et al. Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death Dis. 2021;12:375 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig s8b
Barry D, Liu X, Liu B, Liu X, Gao F, Zeng X, et al. Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors. Nat Commun. 2020;11:1397 pubmed publisher
  • immunohistochemistry; mouse; 1:300; loading ...; fig 2b
Vigouroux R, Cesar Q, Chedotal A, Nguyen Ba Charvet K. Revisiting the role of Dcc in visual system development with a novel eye clearing method. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1e'
Wang L, Xie J, Zhang H, Tsang L, Tsang S, Braune E, et al. Notch signalling regulates epibranchial placode patterning and segregation. Development. 2020;147: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 2a
Pan H, Fatima M, Li A, Lee H, Cai W, Horwitz L, et al. Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch. Neuron. 2019;103:1135-1149.e6 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 2b
Gutierrez Mecinas M, Bell A, Shepherd F, Polgár E, Watanabe M, Furuta T, et al. Expression of cholecystokinin by neurons in mouse spinal dorsal horn. J Comp Neurol. 2019;527:1857-1871 pubmed publisher
  • immunohistochemistry - frozen section; little skate; fig s1b
Jung H, Baek M, D Elia K, Boisvert C, Currie P, Tay B, et al. The Ancient Origins of Neural Substrates for Land Walking. Cell. 2018;172:667-682.e15 pubmed publisher
  • immunohistochemistry - paraffin section; cane toad; loading ...; fig 12a
Smith R, Huang Y, Tian T, Vojtasova D, Mesalles Naranjo O, Pollard S, et al. The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk. J Neurosci. 2017;37:7975-7993 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 1b
Feng W, Kawauchi D, Körkel Qu H, Deng H, Serger E, Sieber L, et al. Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Nat Commun. 2017;8:14758 pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig 3e
Subashini C, Dhanesh S, Chen C, Riya P, Meera V, Divya T, et al. Wnt5a is a crucial regulator of neurogenesis during cerebellum development. Sci Rep. 2017;7:42523 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 5-s1a
Hachisuka J, Baumbauer K, Omori Y, Snyder L, Koerber H, Ross S. Semi-intact ex vivo approach to investigate spinal somatosensory circuits. elife. 2016;5: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig 2a
Kahn B, Corman T, Lovelace K, Hong M, Krauss R, Epstein D. Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia. Dis Model Mech. 2017;10:29-37 pubmed publisher
  • immunohistochemistry; mouse; 1:250; loading ...; fig s5g
Li Y, Tzatzalos E, Kwan K, Grumet M, Cai L. Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development. Sci Rep. 2016;6:38665 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig s2b
Dimidschstein J, Chen Q, Tremblay R, Rogers S, Saldi G, Guo L, et al. A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2016;19:1743-1749 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2
Balázs A, Mészár Z, Hegedűs K, Kenyeres A, Hegyi Z, Dócs K, et al. Development of putative inhibitory neurons in the embryonic and postnatal mouse superficial spinal dorsal horn. Brain Struct Funct. 2017;222:2157-2171 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4m
Xu J, Liu H, Chai O, Lan Y, Jiang R. Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis. PLoS ONE. 2016;11:e0159597 pubmed publisher
  • flow cytometry; human; fig 3
  • immunocytochemistry; human; fig 3
  • immunocytochemistry; mouse; fig 5
Du C, Narayanan K, Leong M, Ibrahim M, Chua Y, Khoo V, et al. Functional Kidney Bioengineering with Pluripotent Stem-Cell-Derived Renal Progenitor Cells and Decellularized Kidney Scaffolds. Adv Healthc Mater. 2016;5:2080-91 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 1
Cai X, Kardon A, Snyder L, Kuzirian M, Minestro S, de Souza L, et al. Bhlhb5::flpo allele uncovers a requirement for Bhlhb5 for the development of the dorsal cochlear nucleus. Dev Biol. 2016;414:149-60 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 4
Wefers A, Lindner S, Schulte J, Schüller U. Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum. Cerebellum. 2017;16:122-131 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Forbes M, Thornhill B, Galarreta C, Chevalier R. A population of mitochondrion-rich cells in the pars recta of mouse kidney. Cell Tissue Res. 2016;363:791-803 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:5
Madrigal M, Moreno Bravo J, Martínez López J, Martínez S, Puelles E. Mesencephalic origin of the rostral Substantia nigra pars reticulata. Brain Struct Funct. 2016;221:1403-12 pubmed publisher
Miranda C, Heged xfc s K, Kis G, Antal M. Synaptic Targets of Glycinergic Neurons in Laminae I-III of the Spinal Dorsal Horn. Int J Mol Sci. 2023;24: pubmed publisher
Cossec J, Traboulsi T, Sart S, Loe Mie Y, Guthmann M, Hendriks I, et al. Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures. Cell Rep. 2023;42:112380 pubmed publisher
Polg xe1 r E, Dickie A, Gutierrez Mecinas M, Bell A, Boyle K, Quillet R, et al. Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain. Pain. 2023;164:149-170 pubmed publisher
Nishida K, Matsumura S, Kobayashi T. Involvement of Brn3a-positive spinal dorsal horn neurons in the transmission of visceral pain in inflammatory bowel disease model mice. Front Pain Res (Lausanne). 2022;3:979038 pubmed publisher
Davis J, Kennedy C, Clerkin S, Treacy N, Dodd T, Moss C, et al. Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids. Commun Biol. 2022;5:1301 pubmed publisher
Ramirez M, Badayeva Y, Yeung J, Wu J, Abdalla Wyse A, Yang E, et al. Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions. elife. 2022;11: pubmed publisher
Mullen R, Bellessort B, Levi G, Behringer R. Distal-less homeobox genes Dlx5/6 regulate Müllerian duct regression. Front Endocrinol (Lausanne). 2022;13:916173 pubmed publisher
Gupta S, Kawaguchi R, Heinrichs E, Gallardo S, Castellanos S, Mandric I, et al. In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion. Cell Rep. 2022;40:111119 pubmed publisher
Li W, Chen L, Fleming J, Brignola E, Zavalin K, Lagrange A, et al. Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning. J Neurosci. 2022;42:5130-5143 pubmed publisher
Gao C, Zhang L, Chen E, Zhang W. Aqp2+ Progenitor Cells Maintain and Repair Distal Renal Segments. J Am Soc Nephrol. 2022;33:1357-1376 pubmed publisher
Yan Y, Shi H, Zhao Z, Wang S, Zhou S, Mu Y, et al. Adiponectin deficiency promotes endometrial carcinoma pathogenesis and development via activation of mitogen-activated protein kinase. J Pathol. 2022;257:146-157 pubmed publisher
Gao D, Yu P, Jing S, Yan C, Ding D, Qiao Y, et al. miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney. Can J Physiol Pharmacol. 2022;100:26-34 pubmed publisher
Miranda C, Heged xfc s K, Wildner H, Zeilhofer H, Antal M. Morphological and neurochemical characterization of glycinergic neurons in laminae I-IV of the mouse spinal dorsal horn. J Comp Neurol. 2022;530:607-626 pubmed publisher
Bond K, Chiba T, Wynne K, Vary C, Sims Lucas S, Coburn J, et al. The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma Determines Cancer Associated Fibroblast Growth. Cancers (Basel). 2021;13: pubmed publisher
Ford M, Harwalkar K, Pacis A, Maunsell H, Wang Y, Badescu D, et al. Oviduct epithelial cells constitute two developmentally distinct lineages that are spatially separated along the distal-proximal axis. Cell Rep. 2021;36:109677 pubmed publisher
Terrey M, Adamson S, Chuang J, Ackerman S. Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology. elife. 2021;10: pubmed publisher
Chang S, Su Y, Chang M, Chen J. MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs. elife. 2021;10: pubmed publisher
Varga A, M xe9 sz xe1 r Z, Sivad xf3 M, B xe1 cskai T, V xe9 gh B, K xf3 kai x, et al. Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents. Int J Mol Sci. 2021;22: pubmed publisher
Gatto G, Bourane S, Ren X, Di Costanzo S, Fenton P, Halder P, et al. A Functional Topographic Map for Spinal Sensorimotor Reflexes. Neuron. 2021;109:91-104.e5 pubmed publisher
Wiedmann N, Wong A, Keast J, Osborne P. Sex differences in c-Fos and EGR-1/Zif268 activity maps of rat sacral spinal cord following cystometry-induced micturition. J Comp Neurol. 2021;529:311-326 pubmed publisher
Chen S, Gao X, Zhou Y, Liu B, Liu X, Zhang Y, et al. A spinal neural circuitry for converting touch to itch sensation. Nat Commun. 2020;11:5074 pubmed publisher
Obert L, Suttie A, Abdi M, Gales T, Dwyer D, FRITZ W, et al. Congenital Unilateral Renal Aplasia in a Cynomolgus Monkey (Macaca fascicularis) With Investigation Into Potential Pathogenesis. Toxicol Pathol. 2020;48:766-783 pubmed publisher
Brewer C, Styczynski L, Serafin E, Baccei M. Postnatal maturation of spinal dynorphin circuits and their role in somatosensation. Pain. 2020;161:1906-1924 pubmed publisher
Liu S, Shu H, Crawford J, Ma Y, Li C, Tao F. Optogenetic Activation of Dopamine Receptor D1 and D2 Neurons in Anterior Cingulate Cortex Differentially Modulates Trigeminal Neuropathic Pain. Mol Neurobiol. 2020;57:4060-4068 pubmed publisher
Yvone G, Chavez Martinez C, Nguyen A, Wang D, Phelps P. Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice. Eur J Neurosci. 2020;52:3322-3338 pubmed publisher
Browne T, Gradwell M, Iredale J, Maden J, Callister R, Hughes D, et al. Transgenic Cross-Referencing of Inhibitory and Excitatory Interneuron Populations to Dissect Neuronal Heterogeneity in the Dorsal Horn. Front Mol Neurosci. 2020;13:32 pubmed publisher
Brewer C, Li J, O Conor K, Serafin E, Baccei M. Neonatal Injury Evokes Persistent Deficits in Dynorphin Inhibitory Circuits within the Adult Mouse Superficial Dorsal Horn. J Neurosci. 2020;40:3882-3895 pubmed publisher
Mona B, Villarreal J, Savage T, Kollipara R, Boisvert B, Johnson J. Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons. Genes Dev. 2020;34:621-636 pubmed publisher
Alharatani R, Ververi A, Beleza Meireles A, Ji W, Mis E, Patterson Q, et al. Novel truncating mutations in CTNND1 cause a dominant craniofacial and cardiac syndrome. Hum Mol Genet. 2020;29:1900-1921 pubmed publisher
Fan W, Sdrulla A. Differential modulation of excitatory and inhibitory populations of superficial dorsal horn neurons in lumbar spinal cord by Aβ-fiber electrical stimulation. Pain. 2020;161:1650-1660 pubmed publisher
Subramanian A, Sidhom E, Emani M, Vernon K, Sahakian N, Zhou Y, et al. Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nat Commun. 2019;10:5462 pubmed publisher
Paixão S, Loschek L, Gaitanos L, Alcalà Morales P, Goulding M, Klein R. Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. Neuron. 2019;104:749-764.e6 pubmed publisher
Faraj R, Irizarry Alfonzo A, Puri P. Molecular characterization of nephron progenitors and their early epithelial derivative structures in the nephrogenic zone of the canine fetal kidney. Eur J Histochem. 2019;63: pubmed publisher
Boyle K, Gradwell M, Yasaka T, Dickie A, Polgár E, Ganley R, et al. Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia. Cell Rep. 2019;28:526-540.e6 pubmed publisher
Kumamaru H, Lu P, Rosenzweig E, Kadoya K, Tuszynski M. Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts. Cell Rep. 2019;26:2329-2339.e4 pubmed publisher
Hariharan K, Reinke P, Kurtz A. Generating Multiple Kidney Progenitors and Cell Types from Human Pluripotent Stem Cells. Methods Mol Biol. 2019;1926:103-115 pubmed publisher
Washausen S, Knabe W. Chicken embryos share mammalian patterns of apoptosis in the posterior placodal area. J Anat. 2019;234:551-563 pubmed publisher
Sasaki H, Sugiyama M, Sasaki N. Establishment of renal proximal tubule cell lines derived from the kidney of p53 knockout mice. Cytotechnology. 2019;71:45-56 pubmed publisher
Verbitsky M, Westland R, Perez A, Kiryluk K, Liu Q, Krithivasan P, et al. The copy number variation landscape of congenital anomalies of the kidney and urinary tract. Nat Genet. 2019;51:117-127 pubmed publisher
Gutierrez Mecinas M, Davis O, Polgár E, Shahzad M, Navarro Batista K, Furuta T, et al. Expression of Calretinin Among Different Neurochemical Classes of Interneuron in the Superficial Dorsal Horn of the Mouse Spinal Cord. Neuroscience. 2019;398:171-181 pubmed publisher
Cerrato V, Parmigiani E, Figueres Oñate M, Betizeau M, Aprato J, Nanavaty I, et al. Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity. PLoS Biol. 2018;16:e2005513 pubmed publisher
Dickie A, Bell A, Iwagaki N, Polgár E, Gutierrez Mecinas M, Kelly R, et al. Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn. Pain. 2019;160:442-462 pubmed publisher
Wang L, Chen S, Ma H, Chen H, Hittelman W, Pan H. Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons. J Neurochem. 2018;147:526-540 pubmed publisher
Bowles J, Feng C, Ineson J, Miles K, Spiller C, Harley V, et al. Retinoic Acid Antagonizes Testis Development in Mice. Cell Rep. 2018;24:1330-1341 pubmed publisher
Musah S, Dimitrakakis N, Camacho D, Church G, Ingber D. Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip. Nat Protoc. 2018;13:1662-1685 pubmed publisher
Obana E, Zhou Q, Furmanski O, Doughty M. Conditional deletion of Neurog1 in the cerebellum of postnatal mice delays inhibitory interneuron maturation. J Neurosci Res. 2018;96:1560-1575 pubmed publisher
Hachisuka J, Omori Y, Chiang M, Gold M, Koerber H, Ross S. Wind-up in lamina I spinoparabrachial neurons: a role for reverberatory circuits. Pain. 2018;159:1484-1493 pubmed publisher
Wang D, Tawfik V, Corder G, Low S, Francois A, Basbaum A, et al. Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron. 2018;98:90-108.e5 pubmed publisher
Huang J, Polgár E, Solinski H, Mishra S, Tseng P, Iwagaki N, et al. Circuit dissection of the role of somatostatin in itch and pain. Nat Neurosci. 2018;21:707-716 pubmed publisher
Gutierrez Mecinas M, Polgár E, Bell A, Herau M, Todd A. Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus. Brain Struct Funct. 2018;223:2377-2392 pubmed publisher
Dawes J, Weir G, Middleton S, Patel R, Chisholm K, Pettingill P, et al. Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability. Neuron. 2018;97:806-822.e10 pubmed publisher
Patel D, Shimomura A, Majumdar S, Holley M, Hashino E. The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLoS ONE. 2018;13:e0191689 pubmed publisher
Puri P, Schaefer C, Bushnell D, Taglienti M, Kreidberg J, Yoder B, et al. Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease. Am J Pathol. 2018;188:84-94 pubmed publisher
Boyle K, Gutierrez Mecinas M, Polgár E, Mooney N, O Connor E, Furuta T, et al. A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord. Neuroscience. 2017;363:120-133 pubmed publisher
Mona B, Uruena A, Kollipara R, Ma Z, Borromeo M, Chang J, et al. Repression by PRDM13 is critical for generating precision in neuronal identity. elife. 2017;6: pubmed publisher
Hagan N, Guarente J, Ellisor D, Zervas M. The Temporal Contribution of the Gbx2 Lineage to Cerebellar Neurons. Front Neuroanat. 2017;11:50 pubmed publisher
Sarkar S, Bristow C, Dey P, Rai K, Perets R, Ramirez Cardenas A, et al. PRKCI promotes immune suppression in ovarian cancer. Genes Dev. 2017;31:1109-1121 pubmed publisher
El Dahr S, Li Y, Liu J, Gutierrez E, Hering Smith K, Signoretti S, et al. p63+ ureteric bud tip cells are progenitors of intercalated cells. JCI Insight. 2017;2: pubmed publisher
Cerqueira D, Bodnar A, Phua Y, Freer R, Hemker S, Walensky L, et al. Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development. FASEB J. 2017;31:3540-3554 pubmed publisher
Hayano Y, Takasu K, Koyama Y, Yamada M, Ogawa K, Minami K, et al. Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B. J Exp Med. 2016;213:2949-2966 pubmed
Takasato M, Er P, Chiu H, Little M. Generation of kidney organoids from human pluripotent stem cells. Nat Protoc. 2016;11:1681-92 pubmed publisher
Zemke M, Draganova K, Klug A, Schöler A, Zurkirchen L, Gay M, et al. Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation. BMC Biol. 2015;13:103 pubmed publisher
Takasato M, Er P, Chiu H, Maier B, Baillie G, Ferguson C, et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature. 2015;526:564-8 pubmed publisher
Shimada M, Dumitrache L, Russell H, McKinnon P. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015;34:2465-80 pubmed publisher
Jiang G, Dai M, Huang K, Chai G, Chen J, Chen L, et al. Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch. Sci Rep. 2015;5:12787 pubmed publisher
Zhang P, Ha T, Larouche M, Swanson D, Goldowitz D. Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. PLoS ONE. 2015;10:e0134390 pubmed publisher
Thiebes K, Nam H, Cambronne X, Shen R, Glasgow S, Cho H, et al. miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3. Nat Commun. 2015;6:7718 pubmed publisher
Wainwright E, Wilhelm D, Combes A, Little M, Koopman P. ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015;404:88-102 pubmed publisher
Zuckermann M, Hovestadt V, Knobbe Thomsen C, Zapatka M, Northcott P, Schramm K, et al. Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nat Commun. 2015;6:7391 pubmed publisher
Vong K, Leung C, Behringer R, Kwan K. Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 2015;8:25 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PAX2 Polyclonal Antibody
Catalog # :
71-6000
Quantity :
100 µg
Price :
US 450.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Ovine, Rat, Xenopus laevis, Zebrafish
Applications :
ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Species :
Human, Mouse, Ovine, Rat, Xenopus laevis, Zebrafish
Isotype :
IgG
Storage :
-20°C
Description :
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.
Immunogen :
A GST-Pax-2 fusion protein derived from the C-terminal domain (aa188-385) of the murine Pax-2 protein
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Aliases :
FSGS7; Opdc; optic disc coloboma; paired box 2; paired box gene 2; paired box homeotic gene 2; paired box protein Pax-2; PAPRS; PAX2; Pax-2
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA