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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
beta Amyloid Polyclonal Antibody
catalog :
71-5800
quantity :
100 µg
price :
US 450.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 25
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:300; loading ...; fig 2a
Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen T, et al. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022;40:111417 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s1a
Chiang A, Fowler S, Reddy R, Pletnikova O, Troncoso J, Sherman M, et al. Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol. 2018;188:739-756 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; fig 1
Wilhelmus M, de Jager M, Smit A, van der Loo R, Drukarch B. Catalytically active tissue transglutaminase colocalises with Aβ pathology in Alzheimer's disease mouse models. Sci Rep. 2016;6:20569 pubmed publisher
DeBay D, Phi T, Bowen C, Burrell S, Darvesh S. No difference in cerebral perfusion between the wild-type and the 5XFAD mouse model of Alzheimer's disease. Sci Rep. 2022;12:22174 pubmed publisher
Pa x10d esov xe1 A, Holubov xe1 M, Hrub xe1 L, Strnadov xe1 V, Nepra x161 ov xe1 B, Pelantov xe1 H, et al. Age-related metabolic and neurodegenerative changes in SAMP8 mice. Aging (Albany NY). 2022;14:7300-7327 pubmed publisher
Gannon O, Robison L, Salinero A, Abi Ghanem C, Mansour F, Kelly R, et al. High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner. J Neuroinflammation. 2022;19:110 pubmed publisher
Machhi J, Yeapuri P, Markovic M, Patel M, Yan W, Lu Y, et al. Europium-Doped Cerium Oxide Nanoparticles for Microglial Amyloid Beta Clearance and Homeostasis. ACS Chem Neurosci. 2022;13:1232-1244 pubmed publisher
Abd Elrahman K, Sarasija S, Colson T, Ferguson S. A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice. Br J Pharmacol. 2022;179:1769-1783 pubmed publisher
Machhi J, Yeapuri P, Lu Y, Foster E, Chikhale R, Herskovitz J, et al. CD4+ effector T cells accelerate Alzheimer's disease in mice. J Neuroinflammation. 2021;18:272 pubmed publisher
Moser V, Workman M, Hurwitz S, Lipman R, Pike C, Svendsen C. Microglial transcription profiles in mouse and human are driven by APOE4 and sex. iScience. 2021;24:103238 pubmed publisher
Jagirdar R, Fu C, Park J, Corbett B, Seibt F, Beierlein M, et al. Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Aβ accumulation in mice. Sci Transl Med. 2021;13:eabh4284 pubmed publisher
Balczon R, Morrow K, Leavesley S, Francis C, Stevens T, Agwaramgbo E, et al. Cystatin C regulates the cytotoxicity of infection-induced endothelial-derived β-amyloid. FEBS Open Bio. 2020;10:2464-2477 pubmed publisher
Christensen A, Liu J, Pike C. Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice. Front Aging Neurosci. 2020;12:113 pubmed publisher
Christensen A, Pike C. Staining and Quantification of β-Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease. Methods Mol Biol. 2020;2144:211-221 pubmed publisher
Abd Elrahman K, Hamilton A, Albaker A, Ferguson S. mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent. ACS Pharmacol Transl Sci. 2020;3:334-344 pubmed publisher
Tripathy D, Migazzi A, Costa F, Roncador A, Gatto P, Fusco F, et al. Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1-42-mediated toxicity. Neurobiol Dis. 2020;140:104849 pubmed publisher
Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Zhang G, et al. URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease. J Neuroinflammation. 2018;15:137 pubmed publisher
Denver P, English A, McClean P. Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice. Brain Behav Immun. 2018;70:423-434 pubmed publisher
Moser V, Pike C. Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice. Eneuro. 2017;4: pubmed publisher
Christensen A, Pike C. Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice. PLoS ONE. 2017;12:e0178490 pubmed publisher
Macdonald I, Maxwell S, Reid G, Cash M, DeBay D, Darvesh S. Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer's Disease. J Alzheimers Dis. 2017;58:491-505 pubmed publisher
McClean P, Jalewa J, Hölscher C. Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice. Behav Brain Res. 2015;293:96-106 pubmed publisher
de Jager M, Drukarch B, Hofstee M, Brevé J, Jongenelen C, Bol J, et al. Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity. J Neurochem. 2015;134:1116-28 pubmed publisher
Reid G, Darvesh S. Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model. Neuroscience. 2015;298:424-35 pubmed publisher
de Jager M, Boot M, Bol J, Brevé J, Jongenelen C, Drukarch B, et al. The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (Aβ) and colocalizes with deposited Aβ in cerebral amyloid angiopathy. Neuropathol Appl Neurobiol. 2016;42:255-72 pubmed publisher
product information
Product Type :
Antibody
Product Name :
beta Amyloid Polyclonal Antibody
Catalog # :
71-5800
Quantity :
100 µg
Price :
US 450.00
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Isotype :
IgG
Storage :
-20°C
Description :
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.
Immunogen :
A 30 amino acid synthetic peptide derived from the full length (1-43 amino acid) beta-Amyloid peptide
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Aliases :
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid ß; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); Beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTF gamma; CTF-alpha; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; OTTHUMP00000096096; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; PreA4 751; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA