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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
RAB11A Polyclonal Antibody
catalog :
71-5300
quantity :
100 µg
price :
US 465.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
African green monkey, human, mouse, rat, dogs, domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 71
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:100; loading ...; fig 1b, 6
Hess M, Krainer I, Filipek P, Witting B, Gutleben K, Vietor I, et al. Advanced Microscopy for Liver and Gut Ultrastructural Pathology in Patients with MVID and PFIC Caused by MYO5B Mutations. J Clin Med. 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 5a
Cruz D, Mitash N, Farinha C, Swiatecka Urban A. TGF-β1 Augments the Apical Membrane Abundance of Lemur Tyrosine Kinase 2 to Inhibit CFTR-Mediated Chloride Transport in Human Bronchial Epithelia. Front Cell Dev Biol. 2020;8:58 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
  • western blot; mouse; loading ...; fig 5f
Cox C, Lu R, Salcin K, Wilson J. The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation. Cell Mol Gastroenterol Hepatol. 2018;5:145-156 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s4a
Maurya D, Bohm S, Alenius M. Hedgehog signaling regulates ciliary localization of mouse odorant receptors. Proc Natl Acad Sci U S A. 2017;114:E9386-E9394 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5b
Varadaraj A, JENKINS L, Singh P, Chanda A, Snider J, Lee N, et al. TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism. Mol Biol Cell. 2017;28:1195-1207 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s1a
Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, et al. Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nat Commun. 2017;8:14646 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s1e
Vidal Quadras M, Holst M, Francis M, Larsson E, Hachimi M, Yau W, et al. Endocytic turnover of Rab8 controls cell polarization. J Cell Sci. 2017;130:1147-1157 pubmed publisher
  • immunocytochemistry; rat; fig s2a
Dustrude E, Moutal A, Yang X, Wang Y, Khanna M, Khanna R. Hierarchical CRMP2 posttranslational modifications control NaV1.7 function. Proc Natl Acad Sci U S A. 2016;113:E8443-E8452 pubmed publisher
  • immunocytochemistry; dogs; 5 ug/ml; loading ...; fig 2f
Müller S, Wilhelm I, Schubert T, Zittlau K, Imberty A, Madl J, et al. Gb3-binding lectins as potential carriers for transcellular drug delivery. Expert Opin Drug Deliv. 2017;14:141-153 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 2a
  • western blot; human; loading ...; fig 4b
Woodruff G, Reyna S, Dunlap M, van der Kant R, Callender J, Young J, et al. Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations. Cell Rep. 2016;17:759-773 pubmed publisher
  • immunocytochemistry; mouse; 1 ug/ml; loading ...; fig 4b
Hara Y, Fukaya M, Hayashi K, Kawauchi T, Nakajima K, Sakagami H. ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin. Eneuro. 2016;3: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2a
Yang Z, Zimmerman S, Tsunezumi J, Braitsch C, Trent C, Bryant D, et al. Role of CD34 family members in lumen formation in the developing kidney. Dev Biol. 2016;418:66-74 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s1e
Porat Shliom N, Tietgens A, Van Itallie C, Vitale Cross L, Jarnik M, Harding O, et al. Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo. Hepatology. 2016;64:1317-29 pubmed publisher
  • western blot; African green monkey; loading ...; fig 9e
Villarroel Campos D, Henríquez D, Bodaleo F, Oguchi M, Bronfman F, Fukuda M, et al. Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B. J Neurosci. 2016;36:7298-313 pubmed publisher
  • immunocytochemistry; African green monkey; 1:100; fig s1
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, et al. Activation of STING requires palmitoylation at the Golgi. Nat Commun. 2016;7:11932 pubmed publisher
  • immunocytochemistry; dogs; fig 3
Perez Bay A, Schreiner R, Benedicto I, Paz Marzolo M, Banfelder J, Weinstein A, et al. The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells. Nat Commun. 2016;7:11550 pubmed publisher
  • immunocytochemistry; rat; fig 2
Homma Y, Fukuda M. Rabin8 regulates neurite outgrowth in both GEF activity-dependent and -independent manners. Mol Biol Cell. 2016;27:2107-18 pubmed publisher
  • western blot; human; fig 1
Wang L, Lee K, Malonis R, SANCHEZ I, Dynlacht B. Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. elife. 2016;5: pubmed publisher
  • western blot; human; loading ...; fig 6h
Francavilla C, Papetti M, Rigbolt K, Pedersen A, Sigurdsson J, Cazzamali G, et al. Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking. Nat Struct Mol Biol. 2016;23:608-18 pubmed publisher
  • western blot; mouse; fig 6
Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, et al. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun. 2016;7:10594 pubmed publisher
Fu M, Zhang J, Zhao M, Zhang S, Dai L, Ouyang X, et al. Coxiella burnetii Plasmid Effector B Promotes LC3-II Accumulation and Contributes To Bacterial Virulence in a SCID Mouse Model. Infect Immun. 2022;90:e0001622 pubmed publisher
Xu F, Mu J, Teng Y, Zhang X, Sundaram K, Sriwastva M, et al. Restoring Oat Nanoparticles Mediated Brain Memory Function of Mice Fed Alcohol by Sorting Inflammatory Dectin-1 Complex Into Microglial Exosomes. Small. 2021;:e2105385 pubmed publisher
Chandrakumar A, Coyaud E, Marshall C, Ikura M, Raught B, Rottapel R. Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs. J Cell Biol. 2021;220: pubmed publisher
Cejas R, Tamaño Blanco M, Blanco J. Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21). Sci Rep. 2021;11:10981 pubmed publisher
Wu Y, Brennan K, Fernández A, Mc Gee M. Cyclophilin A regulates secretion of tumour-derived extracellular vesicles. Transl Oncol. 2021;14:101112 pubmed publisher
Han J, Ganti K, Sali V, Twigg C, Zhang Y, Manivasagam S, et al. Host factor Rab11a is critical for efficient assembly of influenza A virus genomic segments. PLoS Pathog. 2021;17:e1009517 pubmed publisher
Velasco Estevez M, Koch N, Klejbor I, Laurent S, Dev K, Szutowicz A, et al. EBI2 Is Temporarily Upregulated in MO3.13 Oligodendrocytes during Maturation and Regulates Remyelination in the Organotypic Cerebellar Slice Model. Int J Mol Sci. 2021;22: pubmed publisher
Gao X, Ji C, Wang J, Song X, Zuo R, Zhang J, et al. Maduramicin induces cardiotoxicity via Rac1 signaling-independent methuosis in H9c2 cells. J Appl Toxicol. 2021;41:1937-1951 pubmed publisher
Anquetil T, Solinhac R, Jaffre A, Chicanne G, Viaud J, Darcourt J, et al. PI3KC2β inactivation stabilizes VE-cadherin junctions and preserves vascular integrity. EMBO Rep. 2021;22:e51299 pubmed publisher
Joly J, Hudik E, Lécart S, Roos D, Verkuijlen P, Wrona D, et al. Membrane Dynamics and Organization of the Phagocyte NADPH Oxidase in PLB-985 Cells. Front Cell Dev Biol. 2020;8:608600 pubmed publisher
Carter S, Mamede J, Hope T, Jensen G. Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo. Proc Natl Acad Sci U S A. 2020;117:29702-29711 pubmed publisher
Tebaldi G, Pritchard S, Nicola A. Herpes Simplex Virus Entry by a Nonconventional Endocytic Pathway. J Virol. 2020;94: pubmed publisher
González Gutiérrez A, Lazo O, Bronfman F. The Rab5-Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons. J Neurosci. 2020;40:8042-8054 pubmed publisher
Gubar O, Croisé P, Kropyvko S, Gryaznova T, Tóth P, Blangy A, et al. The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways. J Cell Sci. 2020;133: pubmed publisher
Fernandez de Castro I, Tenorio R, Ortega González P, Knowlton J, Zamora P, Lee C, et al. A modified lysosomal organelle mediates nonlytic egress of reovirus. J Cell Biol. 2020;219: pubmed publisher
Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, et al. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta Neuropathol. 2020;139:1001-1024 pubmed publisher
Teoh J, Subramanian N, Pero M, Bartolini F, Amador A, Kanber A, et al. Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors. Neurobiol Dis. 2020;134:104632 pubmed publisher
Rawat V, Wang S, Sima J, Bar R, Liraz O, Gundimeda U, et al. ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes. J Neurosci. 2019;39:9611-9622 pubmed publisher
Fred S, Laukkanen L, Brunello C, Vesa L, Göös H, Cardon I, et al. Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2. J Biol Chem. 2019;294:18150-18161 pubmed publisher
Nishino H, Saito T, Wei R, Takano T, Tsutsumi K, Taniguchi M, et al. The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking. J Neurosci. 2019;39:9491-9502 pubmed publisher
Furlong R, Lindsay A, Anderson K, Hawkins P, Sullivan A, O Neill C. The Parkinson's disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3. J Cell Sci. 2019;132: pubmed publisher
Runwal G, Stamatakou E, Siddiqi F, Puri C, Zhu Y, Rubinsztein D. LC3-positive structures are prominent in autophagy-deficient cells. Sci Rep. 2019;9:10147 pubmed publisher
Sneeggen M, Pedersen N, Campsteijn C, Haugsten E, Stenmark H, Schink K. WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling. Nat Commun. 2019;10:2850 pubmed publisher
Ghosh M, Lo R, Ivic I, Aguilera B, Qendro V, Devarakonda C, et al. CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration. Sci Signal. 2019;12: pubmed publisher
Alenquer M, Vale Costa S, Etibor T, Ferreira F, Sousa A, Amorim M. Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reticulum exit sites. Nat Commun. 2019;10:1629 pubmed publisher
Koike S, Jahn R. SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors. Nat Commun. 2019;10:1608 pubmed publisher
Goto Ito S, Morooka N, Yamagata A, Sato Y, Sato K, Fukai S. Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5. Life Sci Alliance. 2019;2: pubmed publisher
Moya Alvarado G, Gonzalez A, Stuardo N, Bronfman F. Brain-Derived Neurotrophic Factor (BDNF) Regulates Rab5-Positive Early Endosomes in Hippocampal Neurons to Induce Dendritic Branching. Front Cell Neurosci. 2018;12:493 pubmed publisher
Shitara A, Malec L, Ebrahim S, Chen D, Bleck C, Hoffman M, et al. Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals. Mol Biol Cell. 2019;30:324-332 pubmed publisher
Schätzle P, Esteves da Silva M, Tas R, Katrukha E, Hu H, Wierenga C, et al. Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry. Curr Biol. 2018;28:2081-2093.e6 pubmed publisher
Ritt M, Sivaramakrishnan S. Engaging myosin VI tunes motility, morphology and identity in endocytosis. Traffic. 2018;: pubmed publisher
Augustin H, McGourty K, Allen M, Adcott J, Wong C, Boucrot E, et al. Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging. 2018;66:149-157 pubmed publisher
Radif Y, Ndiaye H, Kalantzi V, Jacobs R, Hall A, Minogue S, et al. The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells. Mol Cell Biochem. 2018;448:275-286 pubmed publisher
Søreng K, Munson M, Lamb C, Bjørndal G, Pankiv S, Carlsson S, et al. SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2. EMBO Rep. 2018;19: pubmed publisher
Drecourt A, Babdor J, Dussiot M, Petit F, Goudin N, Garfa Traoré M, et al. Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation. Am J Hum Genet. 2018;102:266-277 pubmed publisher
Rödiger M, Werno M, Wilhelmi I, Baumeier C, Hesse D, Wettschureck N, et al. Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes. Mol Metab. 2018;8:167-179 pubmed publisher
de Castro Martín I, Fournier G, Sachse M, Pizarro Cerda J, Risco C, Naffakh N. Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles. Nat Commun. 2017;8:1396 pubmed publisher
Ramos Nascimento A, Kellen B, Ferreira F, Alenquer M, Vale Costa S, Raposo G, et al. KIF13A mediates trafficking of influenza A virus ribonucleoproteins. J Cell Sci. 2017;130:4038-4050 pubmed publisher
Mazzotti C, Gagliostro V, Bosisio D, Del Prete A, Tiberio L, Thelen M, et al. The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells. Front Immunol. 2017;8:1233 pubmed publisher
Hong Z, Pedersen N, Wang L, Torgersen M, Stenmark H, Raiborg C. PtdIns3P controls mTORC1 signaling through lysosomal positioning. J Cell Biol. 2017;216:4217-4233 pubmed publisher
Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, et al. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 2017;13:e1006603 pubmed publisher
Eva R, Koseki H, Kanamarlapudi V, Fawcett J. EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment. J Cell Sci. 2017;130:3663-3675 pubmed publisher
Koseki H, Donega M, Lam B, Petrova V, van Erp S, Yeo G, et al. Selective rab11 transport and the intrinsic regenerative ability of CNS axons. elife. 2017;6: pubmed publisher
Vogel G, van Rijn J, Krainer I, Janecke A, Posovszky C, Cohen M, et al. Disrupted apical exocytosis of cargo vesicles causes enteropathy in FHL5 patients with Munc18-2 mutations. JCI Insight. 2017;2: pubmed publisher
Vogel G, Janecke A, Krainer I, Gutleben K, Witting B, Mitton S, et al. Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease. Traffic. 2017;18:453-464 pubmed publisher
Li J, Chen Z, Stang M, Gao W. Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes. Autophagy. 2017;13:345-358 pubmed publisher
Chamberland J, Antonow L, Dias Santos M, Ritter B. NECAP2 controls clathrin coat recruitment to early endosomes for fast endocytic recycling. J Cell Sci. 2016;129:2625-37 pubmed publisher
Vale Costa S, Alenquer M, Sousa A, Kellen B, Ramalho J, Tranfield E, et al. Influenza A virus ribonucleoproteins modulate host recycling by competing with Rab11 effectors. J Cell Sci. 2016;129:1697-710 pubmed publisher
Cabasso O, Pekar O, Horowitz M. SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment. PLoS ONE. 2015;10:e0134053 pubmed publisher
Franssen E, Zhao R, Koseki H, Kanamarlapudi V, Hoogenraad C, Eva R, et al. Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS. J Neurosci. 2015;35:8359-75 pubmed publisher
van Bergeijk P, Adrian M, Hoogenraad C, Kapitein L. Optogenetic control of organelle transport and positioning. Nature. 2015;518:111-114 pubmed publisher
product information
Product Type :
Antibody
Product Name :
RAB11A Polyclonal Antibody
Catalog # :
71-5300
Quantity :
100 µg
Price :
US 465.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Canine, Human, Mouse, Non-human primate, Rabbit, Rat
Applications :
ELISA: 0.1-1 µg/mL, Immunocytochemistry: 1-5 µg, Immunohistochemistry (Paraffin): 1:10-1:100, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 5 µg, Western Blot: 1-2 µg/mL
Species :
Canine, Human, Mouse, Non-human primate, Rabbit, Rat
Isotype :
IgG
Storage :
-20°C
Description :
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
Immunogen :
Synthetic peptide derived from the C-terminal hypervariable region of the human Rab11a sequence. This peptide shares 10 of 17 residues with the related Rab11b protein.
Format :
Liquid
Applications w/Dilutions :
ELISA: 0.1-1 µg/mL, Immunocytochemistry: 1-5 µg, Immunohistochemistry (Paraffin): 1:10-1:100, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 5 µg, Western Blot: 1-2 µg/mL
Aliases :
24KG; RAB 11A, member oncogene family; RAB11; rab-11; rab11 GTP-binding protein; Rab11a; RAB11a, member RAS oncogene family; ras-related protein Rab-11A; tubulovesicle-associated protein; YL8
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA