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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Connexin 43 Polyclonal Antibody
catalog :
71-0700
quantity :
50 µg
price :
US 446.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
African green monkey, human, mouse, rat, dogs, domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 70
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 1i
  • western blot; mouse; loading ...; fig 4h
Wang Y, Su Y, Yu G, Wang X, Chen X, Yu B, et al. Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress. Adv Sci (Weinh). 2021;8:e2101181 pubmed publisher
  • western blot; human; loading ...; fig 5c
Wang R, Yu R, Zhu C, Lin H, Lu X, Wang H. Tubulin detyrosination promotes human trophoblast syncytium formation. J Mol Cell Biol. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 3a
Piantanida A, Acosta L, Brocardo L, Capurro C, Greer C, Rela L. Selective Cre-mediated gene deletion identifies connexin 43 as the main connexin channel supporting olfactory ensheathing cell networks. J Comp Neurol. 2019;527:1278-1289 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 8c
Katsumata O, Mori M, Sawane Y, Niimura T, Ito A, Okamoto H, et al. Cellular and subcellular localization of ADP-ribosylation factor 6 in mouse peripheral tissues. Histochem Cell Biol. 2017;148:577-596 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 2d
Guo R, Si R, Scott B, Makino A. Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells. Am J Physiol Cell Physiol. 2017;312:C398-C406 pubmed publisher
  • immunohistochemistry - frozen section; rat; fig 2a
Dergilev K, Makarevich P, Tsokolaeva Z, Boldyreva M, Beloglazova I, Zubkova E, et al. Comparison of cardiac stem cell sheets detached by Versene solution and from thermoresponsive dishes reveals similar properties of constructs. Tissue Cell. 2017;49:64-71 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 1g
Nguyen H, Kirkton R, Bursac N. Engineering prokaryotic channels for control of mammalian tissue excitability. Nat Commun. 2016;7:13132 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 3a
Wagner A, Glenske K, Wolf V, Fietz D, Mazurek S, Hanke T, et al. Osteogenic differentiation capacity of human mesenchymal stromal cells in response to extracellular calcium with special regard to connexin 43. Ann Anat. 2017;209:18-24 pubmed publisher
  • immunohistochemistry; dogs; loading ...; fig 1b
  • western blot; dogs; loading ...; fig 1a
Ponce A, Larre I, Castillo A, Flores Maldonado C, Verdejo Torres O, Contreras R, et al. Ouabain Modulates the Distribution of Connexin 43 in Epithelial Cells. Cell Physiol Biochem. 2016;39:1329-38 pubmed publisher
  • western blot; mouse; 1:2000; fig 1c
Choi S, Roh D, Yoon S, Kwon S, Choi H, Han H, et al. Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice. Neuropharmacology. 2016;111:34-46 pubmed publisher
  • immunohistochemistry - frozen section; domestic rabbit; loading ...; fig 5a
Takanari H, Bourgonje V, Fontes M, Raaijmakers A, Driessen H, Jansen J, et al. Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent. Cardiovasc Res. 2016;111:410-21 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100; loading ...; fig 6c
Kang C, Qiao Y, Li G, Baechle K, Camelliti P, Rentschler S, et al. Human Organotypic Cultured Cardiac Slices: New Platform For High Throughput Preclinical Human Trials. Sci Rep. 2016;6:28798 pubmed publisher
  • western blot; rat; 1:500; fig 1
Rodríguez Jiménez F, Alastrue A, Stojkovic M, Erceg S, Moreno Manzano V. Connexin 50 modulates Sox2 expression in spinal-cord-derived ependymal stem/progenitor cells. Cell Tissue Res. 2016;365:295-307 pubmed publisher
  • western blot; rat; 1:400; fig 7
Lee Kubli C, Ingves M, Henry K, Shiao R, Collyer E, Tuszynski M, et al. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016;278:91-104 pubmed publisher
  • western blot; mouse; fig 3
Villarroel Espíndola F, Tapia C, González Stegmaier R, Concha I, Slebe J. Polyglucosan Molecules Induce Mitochondrial Impairment and Apoptosis in Germ Cells Without Affecting the Integrity and Functionality of Sertoli Cells. J Cell Physiol. 2016;231:2142-52 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 8
  • immunocytochemistry; mouse; fig 8
McCutcheon S, Unachukwu U, Thakur A, MAJESKA R, Redenti S, Vazquez M. In vitro formation of neuroclusters in microfluidic devices and cell migration as a function of stromal-derived growth factor 1 gradients. Cell Adh Migr. 2017;11:1-12 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 1
Pinet Charvet C, Geller S, Desroziers E, Ottogalli M, Lomet D, Georgelin C, et al. GnRH Episodic Secretion Is Altered by Pharmacological Blockade of Gap Junctions: Possible Involvement of Glial Cells. Endocrinology. 2016;157:304-22 pubmed publisher
  • western blot; African green monkey
  • immunohistochemistry; rat; 1:400
  • western blot; rat; 1:1000
Nassal M, Werdich A, Wan X, Hoshi M, Deschênes I, Rosenbaum D, et al. Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress. J Cardiovasc Electrophysiol. 2016;27:110-9 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250
Bolte P, Herrling R, Dorgau B, Schultz K, Feigenspan A, Weiler R, et al. Expression and Localization of Connexins in the Outer Retina of the Mouse. J Mol Neurosci. 2016;58:178-92 pubmed publisher
Leroy K, Vilas Boas V, Gijbels E, Vanderborght B, Devisscher L, Cogliati B, et al. Expression of connexins and pannexins in diseased human liver. EXCLI J. 2022;21:1111-1129 pubmed publisher
Leng K, Rose I, Kim H, Xia W, Romero Fernandez W, Rooney B, et al. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022;25:1528-1542 pubmed publisher
de Souza G, Chaves F, Silva J, Pedroso J, Metzger M, Fraz xe3 o R, et al. Gap junctions regulate the activity of AgRP neurons and diet-induced obesity in male mice. J Endocrinol. 2022;255:75-90 pubmed publisher
El Refaey M, Coles S, Musa H, Stevens T, Wallace M, Murphy N, et al. Altered Expression of Zonula occludens-1 Affects Cardiac Na+ Channels and Increases Susceptibility to Ventricular Arrhythmias. Cells. 2022;11: pubmed publisher
Dang R, Wang M, Li X, Wang H, Liu L, Wu Q, et al. Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway. J Neuroinflammation. 2022;19:41 pubmed publisher
El Nachef D, Martinson A, Yang X, Murry C, MacLellan W. High-resolution 3D fluorescent imaging of intact tissues. Int J Cardiol Cardiovasc Dis. 2021;1:1-14 pubmed publisher
Falleni A, Moscato S, Sabbatini A, Bernardeschi M, Bianchi F, Cecchettini A, et al. Subcellular Localization of Connexin 26 in Cardiomyocytes and in Cardiomyocyte-Derived Extracellular Vesicles. Molecules. 2021;26: pubmed publisher
Nardin C, Peres C, Putti S, Orsini T, Colussi C, Mazzarda F, et al. Connexin Hemichannel Activation by S-Nitrosoglutathione Synergizes Strongly with Photodynamic Therapy Potentiating Anti-Tumor Bystander Killing. Cancers (Basel). 2021;13: pubmed publisher
Liang Y, Lyon R, Pellman J, Bradford W, Lange S, Bogomolovas J, et al. Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021;131: pubmed publisher
Daly A, Davidson M, Burdick J. 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels. Nat Commun. 2021;12:753 pubmed publisher
Herrera A, Morcuende S, Talaverón R, Benitez Temino B, Pastor A, Matarredona E. Purinergic Receptor Blockade with Suramin Increases Survival of Postnatal Neural Progenitor Cells In Vitro. Int J Mol Sci. 2021;22: pubmed publisher
D Antonio Chronowska A, D Antonio M, Frazer K. In vitro Differentiation of Human iPSC-derived Cardiovascular Progenitor Cells (iPSC-CVPCs). Bio Protoc. 2020;10:e3755 pubmed publisher
Martins Marques T, Ribeiro Rodrigues T, de Jager S, Zuzarte M, Ferreira C, Cruz P, et al. Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes. Life Sci Alliance. 2020;3: pubmed publisher
Zhang J, Vincent K, Peter A, Klos M, Cheng H, Huang S, et al. Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function. Circ Res. 2020;127:284-297 pubmed publisher
Lucero C, Andrade D, Toledo C, Diaz H, Pereyra K, Díaz Jara E, et al. Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats. Sci Rep. 2020;10:6878 pubmed publisher
Viswanathan P, Sharma Y, Maisuradze L, Tchaikovskaya T, Gupta S. Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease. Exp Mol Pathol. 2020;113:104369 pubmed publisher
Wang M, Smith K, Yu Q, Miller C, Singh K, Sen C. Mitochondrial connexin 43 in sex-dependent myocardial responses and estrogen-mediated cardiac protection following acute ischemia/reperfusion injury. Basic Res Cardiol. 2019;115:1 pubmed publisher
Van Opbergen C, Noorman M, Pfenniger A, Copier J, Vermij S, Li Z, et al. Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress. Int J Mol Sci. 2019;20: pubmed publisher
Roberts J, Murphy N, Hamilton R, Lubbers E, James C, Kline C, et al. Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy. J Clin Invest. 2019;129:3171-3184 pubmed publisher
Bazzoun D, Adissu H, Wang L, Urazaev A, Tenvooren I, Fostok S, et al. Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium. J Cell Sci. 2019;132: pubmed publisher
Végh A, den Haan A, Cócera Ortega L, Verkerk A, Sluijter J, Bakker D, et al. Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing. Molecules. 2019;24: pubmed publisher
Li G, Khandekar A, Yin T, Hicks S, Guo Q, Takahashi K, et al. Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles. J Mol Cell Cardiol. 2018;123:92-107 pubmed publisher
Martinez Palma L, Miquel E, Lagos Rodríguez V, Barbeito L, Cassina A, Cassina P. Mitochondrial Modulation by Dichloroacetate Reduces Toxicity of Aberrant Glial Cells and Gliosis in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis. Neurotherapeutics. 2019;16:203-215 pubmed publisher
Dergilev K, Tsokolaeva Z, Makarevich P, Beloglazova I, Zubkova E, Boldyreva M, et al. C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats. Biomed Res Int. 2018;2018:3536854 pubmed publisher
Hollenbach J, Jung K, Noelke J, Gasse H, Pfarrer C, Koy M, et al. Loss of connexin43 in murine Sertoli cells and its effect on blood-testis barrier formation and dynamics. PLoS ONE. 2018;13:e0198100 pubmed publisher
Shi B, Xue M, Wang Y, Wang Y, Li D, Zhao X, et al. An improved method for increasing the efficiency of gene transfection and transduction. Int J Physiol Pathophysiol Pharmacol. 2018;10:95-104 pubmed
Shaito A, Saliba J, Husari A, El Harakeh M, Chhouri H, Hashem Y, et al. Electronic Cigarette Smoke Impairs Normal Mesenchymal Stem Cell Differentiation. Sci Rep. 2017;7:14281 pubmed publisher
Skiöldebrand E, Lundqvist A, Björklund U, Sandstedt M, Lindahl A, Hansson E, et al. Inflammatory activation of human cardiac fibroblasts leads to altered calcium signaling, decreased connexin 43 expression and increased glutamate secretion. Heliyon. 2017;3:e00406 pubmed publisher
Rebourcet D, Darbey A, Monteiro A, Soffientini U, Tsai Y, Handel I, et al. Sertoli Cell Number Defines and Predicts Germ and Leydig Cell Population Sizes in the Adult Mouse Testis. Endocrinology. 2017;158:2955-2969 pubmed publisher
Wang S, Tsao D, Vanderpool K, Yasumura T, Rash J, Nagy J. Connexin36 localization to pinealocytes in the pineal gland of mouse and rat. Eur J Neurosci. 2017;45:1594-1605 pubmed publisher
Tsao D, Wang S, Lynn B, Nagy J. Immunofluorescence reveals unusual patterns of labelling for connexin43 localized to calbindin-D28K-positive interstitial cells in the pineal gland. Eur J Neurosci. 2017;45:1553-1569 pubmed publisher
Rondanino C, Maouche A, Dumont L, Oblette A, Rives N. Establishment, maintenance and functional integrity of the blood-testis barrier in organotypic cultures of fresh and frozen/thawed prepubertal mouse testes. Mol Hum Reprod. 2017;23:304-320 pubmed publisher
Nassal M, Wan X, Dale Z, Deschênes I, Wilson L, Piktel J. Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and Na+ channel function. Am J Physiol Heart Circ Physiol. 2017;312:H886-H895 pubmed publisher
Munger S, Geng X, Srinivasan R, Witte M, Paul D, Simon A. Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice. Dev Biol. 2016;412:173-90 pubmed publisher
Wang S, Li H, Yu L, Chen M, Wang Z, Huang B, et al. Anti-arrhythmic effects of atrial ganglionated plexi stimulation is accompanied by preservation of connexin43 protein in ischemia-reperfusion canine model. Int J Clin Exp Med. 2015;8:22098-107 pubmed
Liu L, Li C, Lu Y, Zong X, Luo C, Sun J, et al. Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Sci Rep. 2015;5:14474 pubmed publisher
Han X, He D, Xu L, Chen M, Wang Y, Feng J, et al. Knockdown of connexin 43 attenuates balloon injury-induced vascular restenosis through the inhibition of the proliferation and migration of vascular smooth muscle cells. Int J Mol Med. 2015;36:1361-8 pubmed publisher
Basheer W, Harris B, Mentrup H, Abreha M, Thames E, Lea J, et al. Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis. J Mol Cell Cardiol. 2015;88:1-13 pubmed publisher
Thuringer D, Berthenet K, Cronier L, Solary E, Garrido C. Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells. Oncotarget. 2015;6:28800-15 pubmed publisher
Noritake K, Aki T, Funakoshi T, Unuma K, Uemura K. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015;10:e0136952 pubmed publisher
Fontes M, Papazova D, van Koppen A, de Jong S, Korte S, Bongartz L, et al. Arrhythmogenic Remodeling in Murine Models of Deoxycorticosterone Acetate-Salt-Induced and 5/6-Subtotal Nephrectomy-Salt-Induced Cardiorenal Disease. Cardiorenal Med. 2015;5:208-18 pubmed publisher
Jiang H, Zhao L, Dong X, He A, Zheng C, Johansson M, et al. Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria. Oncol Rep. 2015;34:1487-93 pubmed publisher
Fontes J, Ramsey J, Polk J, Koop A, Denisova J, Belousov A. Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. PLoS ONE. 2015;10:e0125395 pubmed publisher
Zhang D, Zhu L, Li C, Mu J, Fu Y, Zhu Q, et al. Sialyltransferase7A, a Klf4-responsive gene, promotes cardiomyocyte apoptosis during myocardial infarction. Basic Res Cardiol. 2015;110:28 pubmed publisher
Rela L, Piantanida A, Bordey A, Greer C. Voltage-dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells. Glia. 2015;63:1646-59 pubmed publisher
Vairo L, Medei E, Dos Santos D, Rodrigues D, Goldenberg R, de Carvalho A. Functional properties of a Brazilian derived mouse embryonic stem cell line. An Acad Bras Cienc. 2015;87:275-88 pubmed publisher
Han X, Chen M, Hong T, Zhu L, He D, Feng J, et al. Lentivirus-mediated RNAi knockdown of the gap junction protein, Cx43, attenuates the development of vascular restenosis following balloon injury. Int J Mol Med. 2015;35:885-92 pubmed publisher
Liu K, Lyu L, Chin D, Gao J, Sun X, Shang F, et al. Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract. Proc Natl Acad Sci U S A. 2015;112:1071-6 pubmed publisher
Mroue R, INMAN J, Mott J, Budunova I, Bissell M. Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland. Dev Biol. 2015;399:15-26 pubmed publisher
Swager S, Delfín D, Rastogi N, Wang H, Canan B, Fedorov V, et al. Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1. Cardiovasc Pathol. 2015;24:160-167 pubmed publisher
Kuhlmann M, Kirchhof P, Klocke R, Hasib L, Stypmann J, Fabritz L, et al. G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis. J Exp Med. 2006;203:87-97 pubmed
product information
Product Type :
Antibody
Product Name :
Connexin 43 Polyclonal Antibody
Catalog # :
71-0700
Quantity :
50 µg
Price :
US 446.00
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Frozen): 1-5 µg/mL, Immunohistochemistry (Paraffin): 1-5 µg/mL, Western Blot: 2-4 µg/mL
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20°C
Description :
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication. GFAP are membrane-spanning proteins that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is also targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. Mutations in the GFAP gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy, oculodentodigital dysplasia and heart malformations. Alternatively spliced transcript variants of GFAP have been found.
Immunogen :
Peptide corresponding to a segment of the 3rd cytoplasmic domain (C-terminal portion) of rat connexin 43.
Format :
Liquid
Applications w/Dilutions :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Frozen): 1-5 µg/mL, Immunohistochemistry (Paraffin): 1-5 µg/mL, Western Blot: 2-4 µg/mL
Aliases :
alpha 1 connexin; AU042049; AVSD3; AW546267; CMDR; Cnx43; connexin 43; connexin43; connexin-43; cx43; Cx-43; cx43 protein; cx43a1; Cx43alpha1; CXA1; Cxn-43; DFNB38; EKVP; etID309742.9; gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein; gap junction membrane channel protein alpha 1; gap junction protein; gap junction protein alpha 1; gap junction protein connexin 43; gap junction protein, alpha 1; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; gap junction protein, alpha 1, 43kDa (connexin 43); gja1; Gja-1; GJAL; HLHS1; HSS; Npm1; ODD; ODDD; ODOD; PPKCA; SDTY3; shf; Short fin protein; sof; stopsel; stp; Syndactyly type III; vascular smooth muscle connexin43; Vascular smooth muscle connexin-43; zfCx43.3
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA