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company name :
Invitrogen
other brands :
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product type :
antibody
product name :
Connexin 26 Polyclonal Antibody
catalog :
71-0500
quantity :
50 µg
price :
US 430.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 17
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 6f
Miwa T, Wei F, Tomizawa K. Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss. Mol Brain. 2021;14:82 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4c
Miwa T. Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein. Front Cell Neurosci. 2021;15:634868 pubmed publisher
  • western blot; human; 1:1000; loading ...
Hosoya M, Fujioka M, Sone T, Okamoto S, Akamatsu W, Ukai H, et al. Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss. Cell Rep. 2017;18:68-81 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Zhou X, Chen S, Xie L, Ji Y, Wu X, Wang W, et al. Reduced Connexin26 in the Mature Cochlea Increases Susceptibility to Noise-Induced Hearing Lossin Mice. Int J Mol Sci. 2016;17:301 pubmed publisher
  • immunohistochemistry - paraffin section; rat; fig s3
  • western blot; rat; fig s2
Nüsken E, Gellhaus A, Kühnel E, Swoboda I, Wohlfarth M, Vohlen C, et al. Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming. J Cell Biochem. 2016;117:1594-603 pubmed publisher
Nardin C, Tettey Matey A, Donati V, Marazziti D, Di Pietro C, Peres C, et al. A Quantitative Assay for Ca2+ Uptake through Normal and Pathological Hemichannels. Int J Mol Sci. 2022;23: pubmed publisher
Zhang L, Wang W, Kim S, Wang J, Zhou B, Kong W, et al. Virally Mediated Connexin 26 Expression in Postnatal Scala Media Significantly and Transiently Preserves Hearing in Connexin 30 Null Mice. Front Cell Dev Biol. 2022;10:900416 pubmed publisher
Liu X, Jin Y, Chen S, Xu K, Xie L, Qiu Y, et al. F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model. Front Mol Neurosci. 2021;14:808553 pubmed publisher
Cao C, Fleming M. Localization and Kinetics of the Transferrin-Dependent Iron Transport Machinery in the Mouse Placenta. Curr Dev Nutr. 2021;5:nzab025 pubmed publisher
Su L, Wang Z, Xie S, Hu D, Cheng Y, Mruk D, et al. Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization. J Cell Physiol. 2020;235:6127-6138 pubmed publisher
Lee M, Wang H, White T, Brooks T, Pittman A, Halai H, et al. Allele-Specific Small Interfering RNA Corrects Aberrant Cellular Phenotype in Keratitis-Ichthyosis-Deafness Syndrome Keratinocytes. J Invest Dermatol. 2020;140:1035-1044.e7 pubmed publisher
Miwa T, Minoda R, Ishikawa Y, Kajii T, Orita Y, Ohyama T. Role of Dach1 revealed using a novel inner ear-specific Dach1-knockdown mouse model. Biol Open. 2019;8: pubmed publisher
Tsao D, Wang S, Lynn B, Nagy J. Immunofluorescence reveals unusual patterns of labelling for connexin43 localized to calbindin-D28K-positive interstitial cells in the pineal gland. Eur J Neurosci. 2017;45:1553-1569 pubmed publisher
Molina S, Stauffer B, Moriarty H, Kim A, McCarty N, Koval M. Junctional abnormalities in human airway epithelial cells expressing F508del CFTR. Am J Physiol Lung Cell Mol Physiol. 2015;309:L475-87 pubmed publisher
Meyer Zum Gottesberge A, Massing T, Sasse A, Palma S, Hansen S. Zucker diabetic fatty rats, a model for type 2 diabetes, develop an inner ear dysfunction that can be attenuated by losartan treatment. Cell Tissue Res. 2015;362:307-15 pubmed publisher
Zonta F, Girotto G, Buratto D, Crispino G, Morgan A, Abdulhadi K, et al. The p.Cys169Tyr variant of connexin 26 is not a polymorphism. Hum Mol Genet. 2015;24:2641-8 pubmed publisher
Chang Q, Tang W, Kim Y, Lin X. Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events before the onset of hearing. Neurobiol Dis. 2015;73:418-27 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Connexin 26 Polyclonal Antibody
Catalog # :
71-0500
Quantity :
50 µg
Price :
US 430.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Mouse, Rat
Applications :
ELISA: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 2 µg/mL
Species :
Mouse, Rat
Isotype :
IgG
Storage :
-20°C
Description :
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
Immunogen :
Peptide corresponding to a portion of the cytoplasmic loop of rat connexin 26.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 2 µg/mL
Aliases :
AI325222; Cnx26; connexin 26; connexin-26; CX26; CXN-26; DFNA3; DFNA3A; DFNB1; DFNB1A; Gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; gap junction protein beta 2; gap junction protein, beta 2; gap junction protein, beta 2, 26kDa; GJB2; Gjb-2; HID; KID; mutant gap junction protein beta 2; NSRD1; PPK
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA