TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17) | Invitrogen 703809 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)

catalog :

703809

quantity :

100 ug

price :

US 520.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

10H7L17

reactivity :

human

application :

western blot, immunocytochemistry

citations: 2

Reference
Woappi Y, Altomare D, Creek K, Pirisi L. Self-assembling 3D spheroid cultures of human neonatal keratinocytes have enhanced regenerative properties. Stem Cell Res. 2020;49:102048 pubmed publisher
Shan N, Minden A, FURMANSKI P, Bak M, Cai L, Wernyj R, et al. Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds. Cancer Prev Res (Phila). 2020;13:673-686 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)

Catalog # :

703809

Quantity :

100 ug

Price :

US 520.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:100, Western Blot: 1:1,000

Species :

Human

Clone :

10H7L17

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

TP63 (tumor protein 63) acts as a sequence-specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform-specific activity. Isoform 2 activates RIPK4 transcription. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by inducing JAG1 and JAG2. TP63 plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. TP63 is required for limb formation from the apical ectodermal ridge. It also activates transcription of the p21 promoter. Mutations affecting the gene can result in Acro-dermato-ungual-lacrimal-tooth syndrome, ankyloblepharon-ectodermal defects-cleft lip/palate, ectrodactyly ectodermal dysplasia, split-hand/foot malformation 4, limb-mammary syndrome, ectodermal dysplasia - Rapp-Hodgkin type, and orofacial cleft 8.

Immunogen :

Protein corresponding to human TP63 [aa360-aa500]

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Western Blot: 1:1,000

Aliases :

AIS; amplified in squamous cell carcinoma; B(p51A); B(p51B); Chronic ulcerative stomatitis protein; CUSP; EEC3; Keratinocyte transcription factor KET; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p63a; P73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L; Transformation-related protein 63; tumor protein 63; tumor protein p53-competing protein; tumor protein p63; Tumor protein p73-like