CHD8 Recombinant Rabbit Monoclonal Antibody (20H56L8) | Invitrogen 703595 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CHD8 Recombinant Rabbit Monoclonal Antibody (20H56L8)

catalog :

703595

quantity :

100 ug

price :

US 500.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

20H56L8

reactivity :

human

application :

immunocytochemistry

product information

Product Type :

Antibody

Product Name :

CHD8 Recombinant Rabbit Monoclonal Antibody (20H56L8)

Catalog # :

703595

Quantity :

100 ug

Price :

US 500.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ChIP Assay: 2.5 ug/million cells, Immunocytochemistry: 1:100

Species :

Human

Clone :

20H56L8

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.

Immunogen :

Protein corresponding to human CHD8 [aa2291-aa2364]

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 2.5 ug/million cells, Immunocytochemistry: 1:100

Aliases :

5830451P18Rik; ATP-dependent helicase CHD8; AU015341; AUTS18; Axis duplication inhibitor; beta-catenin binding protein; CHD8; CHD-8; chromodomain helicase DNA binding protein 8; chromodomain-helicase-DNA-binding protein 8; Duplin; helicase with SNF2 domain 1; HELSNF1; Kiaa1564; mKIAA1564