TBK1 Recombinant Rabbit Monoclonal Antibody (12H60L39) | Invitrogen 703154 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TBK1 Recombinant Rabbit Monoclonal Antibody (12H60L39)

catalog :

703154

quantity :

100 ug

price :

US 520.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

12H60L39

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 3

Reference
Zhang K, Ge H, Zhou P, Li L, Dai J, Cao H, et al. The D129L protein of African swine fever virus interferes with the binding of transcriptional coactivator p300 and IRF3 to prevent beta interferon induction. J Virol. 2023;97:e0082423 pubmed publisher
Alshafie W, Fotouhi M, Shlaifer I, Ayoubi R, Edwards A, Durcan T, et al. Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence. F1000Res. 2022;11:977 pubmed publisher
Sun M, Yu S, Ge H, Wang T, Li Y, Zhou P, et al. The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1. J Virol. 2022;96:e0195721 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TBK1 Recombinant Rabbit Monoclonal Antibody (12H60L39)

Catalog # :

703154

Quantity :

100 ug

Price :

US 520.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:100, Western Blot: 1:1,000

Species :

Human, Mouse

Clone :

12H60L39

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

Immunogen :

Peptides corresponding to human TBK1 [1) aa18-aa33, 2) aa563-aa577]

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Western Blot: 1:1,000

Aliases :

1200008B05Rik; AI462036; AW048562; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; tbk; TBK1