cGAS Recombinant Rabbit Monoclonal Antibody (10H1L5) | Invitrogen 703149 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

cGAS Recombinant Rabbit Monoclonal Antibody (10H1L5)

catalog :

703149

quantity :

100 ug

price :

US 520.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

10H1L5

reactivity :

mouse

application :

western blot

citations: 1

Reference
Ludwig S x142 omczy x144 ska A, Seweryn M, Wiater J, Borys A, Ledwo x144 A, Druszczy x144 ska M, et al. Cytosolic nucleic acid sensing and mitochondrial transcriptomic changes as early triggers of metabolic disease in db/db mice. Mamm Genome. 2024;35:68-76 pubmed publisher

product information

Product Type :

Antibody

Product Name :

cGAS Recombinant Rabbit Monoclonal Antibody (10H1L5)

Catalog # :

703149

Quantity :

100 ug

Price :

US 520.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Mouse

Applications :

Western Blot: 1:1,000

Species :

Mouse

Clone :

10H1L5

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.

Immunogen :

Protein corresponding to mouse cGAS [aa147-aa507]

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

C6orf150; h-cGAS; MB21D1