ISG15 Recombinant Rabbit Monoclonal Antibody (1H9L21), Alexa Fluor Plus 488 | Invitrogen 703132RP48820UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ISG15 Recombinant Rabbit Monoclonal Antibody (1H9L21), Alexa Fluor Plus 488

catalog :

703132RP48820UG

quantity :

20 uL

price :

US 211.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

1H9L21

reactivity :

mouse

application :

western blot, immunocytochemistry, flow cytometry

product information

Product Type :

Antibody

Product Name :

ISG15 Recombinant Rabbit Monoclonal Antibody (1H9L21), Alexa Fluor Plus 488

Catalog # :

703132RP48820UG

Quantity :

20 uL

Price :

US 211.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25-1.0 ug/test, Immunocytochemistry: 1:50 -1:200, Western Blot: 1:100-1:200

Species :

Mouse

Clone :

1H9L21

Isotype :

IgG

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. It is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MCH (major histocompatibility complex)-restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega, but not IFN-gamma. ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog. Mutations affecting the gene can result in Immunodeficiency 38, with basal ganglia calcification (IMD38).

Immunogen :

Protein corresponding to mouse ISG15 [aa2-aa155]

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25-1.0 ug/test, Immunocytochemistry: 1:50 -1:200, Western Blot: 1:100-1:200

Aliases :

G1P2; hUCRP; IFI15; IGI15; IMD38; interferon, alpha-inducible protein; interferon, alpha-inducible protein (clone IFI-15K); interferon-induced 15 kDa protein; interferon-induced 15-KDa protein; interferon-induced 17 kDa protein; interferon-induced 17-kDa/15-kDa protein; interferon-stimulated protein (15 kDa); interferon-stimulated protein 15; interferon-stimulated protein, 15 kDa; IP17; Irfp; Isg15; ISG15 ubiquitin like modifier; ISG15 ubiquitin-like modifier; ubiquitin cross-reactive protein; Ubiquitin-like protein ISG15; UCRP