Phospho-Syk (Tyr323, Tyr317) Recombinant Rabbit Monoclonal Antibody (6H48L23)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-Syk (Tyr323, Tyr317) Recombinant Rabbit Monoclonal Antibody (6H48L23)

catalog :

702383

quantity :

100 ug

price :

US 450.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

6H48L23

reactivity :

human

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

Phospho-Syk (Tyr323, Tyr317) Recombinant Rabbit Monoclonal Antibody (6H48L23)

Catalog # :

702383

Quantity :

100 ug

Price :

US 450.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 2 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human

Clone :

6H48L23

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

Immunogen :

Peptide corresponding to Human Syk (aa 319-327)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK