Phospho-RSK Pan (Ser221, Ser227, Ser218, Ser232) Recombinant Rabbit Monoclonal Antibody (12H25L15)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-RSK Pan (Ser221, Ser227, Ser218, Ser232) Recombinant Rabbit Monoclonal Antibody (12H25L15)

catalog :

702304

quantity :

100µg

price :

US 331

clonality :

recombinant

host :

rabbit

conjugate :

nonconjugated

clone name :

12H25L15

reactivity :

human, Rhesus monkey

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-RSK Pan (Ser221, Ser227, Ser218, Ser232) Recombinant Rabbit Monoclonal Antibody (12H25L15)

Catalog # :

702304

Quantity :

100µg

Price :

US 331

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Rhesus Monkey

Applications :

Western Blot: 1-2 µg/mL

Species :

Human, Rhesus Monkey

Clone :

12H25L15

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threonine kinases that lie at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1 to-4). RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional. Theses kinase domains are activated in a sequential manner by a series of phosphorylations. RSK regulates gene expression via association and phosphorylation of transcriptional regulators including c-Fos, estrogen receptor, NFkappaB/IkappaB alpha, cAMP-response element-binding protein (CREB). ERK activates the C-terminal kinase of RSK, leading to activation of the N-terminal kinase. Members of the RSK family are present in the cytoplasm as well as the nucleus. Addition of growth factor to the cells results in the activation of both cytosolic and nuclear RSK and the translocation of the cytosolic RSK into the nucleus upon activation. The activation and nuclear translocation of RSK result in phosphorylation and activation of transcription factors.

Immunogen :

Peptide corresponding to human RSK1/RSK2/RSK3/RSK4 (Ser221, 227, 218, 232) ( aa217-225)

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1-2 µg/mL

Aliases :

MAPKAPK1A, RSK1