Phospho-FOXO4 (Thr28) Recombinant Rabbit Monoclonal Antibody (12H2L20)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-FOXO4 (Thr28) Recombinant Rabbit Monoclonal Antibody (12H2L20)

catalog :

701848

quantity :

100 µg

price :

US 410

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

12H2L20

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-FOXO4 (Thr28) Recombinant Rabbit Monoclonal Antibody (12H2L20)

Catalog # :

701848

Quantity :

100 µg

Price :

US 410

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 0.5-1 µg/mL

Species :

Human

Clone :

12H2L20

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7) and is a member of the O class of forkhead/ winged helix family of transcription factors along with FOXO1, FOXO3 and FOXO6. FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. FOXO4 binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. However, the activation of another downstream target of the Insulin/IGF1 pathway, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues. This phosphorylation mediates binding of FOXO4 to 14-3-3 and eventual exit of FOXO4 from the nucleus.

Immunogen :

Phosphopeptide corresponding to Human FoxO4 Thr28 (aa 25-33)

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.5-1 µg/mL

Aliases :

AFX; Afx1; Afxh; AFXzeta; Fkhr3; Fork head domain transcription factor AFX1; forkhead box O4; forkhead box protein O4; forkhead protein; FOXO4; FOXO4b; MGC120490; MLLT7; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; OTTHUMP00000023497; RGD1561201