OCT4 Recombinant Rabbit Monoclonal Antibody (3H8L6) | Invitrogen 701756 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

OCT4 Recombinant Rabbit Monoclonal Antibody (3H8L6)

catalog :

701756

quantity :

100 ug

price :

US 520.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

3H8L6

reactivity :

human, mouse

application :

western blot, immunocytochemistry, ChIP-Seq

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
ChIP-Seq; mouse; loading ...; fig s3a	Hainer S, Boskovic A, McCannell K, Rando O, Fazzio T. Profiling of Pluripotency Factors in Single Cells and Early Embryos. Cell. 2019;: pubmed publisher
	Hovland A, Bhattacharya D, Azambuja A, Pramio D, Copeland J, Rothstein M, et al. Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells. Dev Cell. 2022;57:2257-2272.e5 pubmed publisher
	Hosseini K, Lekholm E, Ahemaiti A, Fredriksson R. Differentiation of Human Embryonic Stem Cells into Neuron, Cholinergic, and Glial Cells. Stem Cells Int. 2020;2020:8827874 pubmed publisher
	Sousa M, Correia B, Branco A, Rodrigues A, Ramalho Santos J. Effects of DMSO on the Pluripotency of Cultured Mouse Embryonic Stem Cells (mESCs). Stem Cells Int. 2020;2020:8835353 pubmed publisher
	Xu X, Pradhan M, Xu M, Cheng Y, Beers J, Linask K, et al. Four induced pluripotent stem cell lines (TRNDi021-C, TRNDi023-D, TRNDi024-D and TRNDi025-A) generated from fibroblasts of four healthy individuals. Stem Cell Res. 2020;49:102011 pubmed publisher
	Patterson K, Beers J, Linask K, Lin Y, Hassanzadeh S, Sack M, et al. Generation of two induced pluripotent stem cell lines (NHLBIi001-A and NHLBIi001-B) from a healthy Caucasian female volunteer with normal cardiac function. Stem Cell Res. 2019;41:101627 pubmed publisher
	Matrone G, Thandavarayan R, Walther B, Meng S, Mojiri A, Cooke J. Dysfunction of iPSC-derived endothelial cells in human Hutchinson-Gilford progeria syndrome. Cell Cycle. 2019;18:2495-2508 pubmed publisher

product information

Product Type :

Antibody

Product Name :

OCT4 Recombinant Rabbit Monoclonal Antibody (3H8L6)

Catalog # :

701756

Quantity :

100 ug

Price :

US 520.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ChIP Assay: 2.5 ug x 10^6 cells, Immunocytochemistry: 1-2 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse

Clone :

3H8L6

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

POU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

Immunogen :

Protein corresponding to Human POU5F1 (aa 1-360)

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 2.5 ug x 10^6 cells, Immunocytochemistry: 1-2 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

2-Oct; 3-Oct; 4-Oct; cb197; chunp6868; DADB-104B20.2; etID49452.21; gp9; gp-9; HGNC:9221; homeobox protein; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; MGC22487; NF-A3; Oct2; Oct-2; Oct2a; Oct2b; OCT3; Oct-3; Oct3/4; Oct-3/4; OCT4; Oct-4; Octamer-binding protein 2; octamer-binding protein 3; Octamer-binding protein 4; octamer-binding transcription factor 2; Octamer-binding transcription factor 3; OTF2; OTF-2; OTF3; Otf-3; Otf3g; Otf3-rs7; Otf4; Otf-4; OTTHUMP00000221150; OTTHUMP00000221151; POU class 2 homeobox 2; POU class 5 homeobox 1; POU class 5 homeobox 1 transcript variant OCT4B1; POU class 5 homeobox 1 transcript variant OCT4B2; POU class 5 homeobox 1 transcript variant OCT4B3; POU class 5 homeobox 1 transcript variant OCT4B4; POU class 5 homeobox 1 transcript variant OCT4B5; POU class 5 homeobox 1 transcript variant OCT4B6; POU domain class 5 transcription factor 1; POU domain gene 2; POU domain protein 2; POU domain transcription factor OCT4; POU domain, class 2, transcription factor 2; POU domain, class 5, transcription factor 1; POU domain, class 5, transcription factor 3; pou2; pou-2; POU2F2; Pou5f1; pou5f1 protein; pou5f3; POU-type homeodomain-containing DNA-binding protein; spg; spg/pou2; spiel-ohne-grenzen; spiel-ohne-grenzen/pou2; wu:fd18d06

more info or order :

Invitrogen product webpage