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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD49f Recombinant Rabbit Monoclonal Antibody (5H14L18)
catalog :
701178
quantity :
100 µg
price :
US 375.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
5H14L18
reactivity :
human, mouse, dogs
application :
western blot
more info or order :
Invitrogen product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:250; loading ...; fig 2b
  • western blot; mouse; 1:250; loading ...; fig 1b
Brooks D, Schwab L, Krutilina R, Parke D, Sethuraman A, Hoogewijs D, et al. ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models. Mol Cancer. 2016;15:26 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD49f Recombinant Rabbit Monoclonal Antibody (5H14L18)
Catalog # :
701178
Quantity :
100 µg
Price :
US 375.00
Clonality :
Recombinant Monoclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Canine, Human, Mouse
Applications :
Western Blot: 2-3 µg/mL
Species :
Canine, Human, Mouse
Clone :
5H14L18
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.
Immunogen :
Recombinant protein corresponding to amino acids 102-299 of human Integrin alpha 6
Format :
Liquid
Applications w/Dilutions :
Western Blot: 2-3 µg/mL
Aliases :
5033401O05Rik; AI115430; Alpha6p; CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; integrin alpha 6; integrin alpha-6; Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; integrin alpha6B; integrin subunit alpha 6; integrin, alpha 6; Itga6; ITGA6B; LOW QUALITY PROTEIN: integrin alpha-6; Processed integrin alpha-6; VLA-6
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA