alpha Synuclein Recombinant Rabbit Monoclonal Antibody (14H2L1)

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

alpha Synuclein Recombinant Rabbit Monoclonal Antibody (14H2L1)

catalog :

701085

quantity :

100 µg

price :

US 375.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

14H2L1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; loading ...; fig 3a immunocytochemistry; human; loading ...; fig 1f	Reyes J, Ekmark Lewén S, Perdiki M, Klingstedt T, Hoffmann A, Wiechec E, et al. Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease. Acta Neuropathol Commun. 2021;9:46 pubmed publisher
western blot; human; 1:1500	Lai Y, Kim S, Varkey J, Lou X, Song J, Diao J, et al. Nonaggregated ?-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 2014;53:3889-96 pubmed publisher
	Moudio S, Rodin F, Albargothy N, Karlsson U, Reyes J, Hallbeck M. Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease. Front Neurol. 2022;13:826102 pubmed publisher
	Calamini B, Geyer N, Huss Braun N, Bernhardt A, Harsany V, Rival P, et al. Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease. Dis Model Mech. 2021;14: pubmed publisher
	Schwab N, Grenier K, Hazrati L. DNA repair deficiency and senescence in concussed professional athletes involved in contact sports. Acta Neuropathol Commun. 2019;7:182 pubmed publisher
	Sackmann V, Sinha M, Sackmann C, Civitelli L, Bergström J, Ansell Schultz A, et al. Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia. Front Mol Neurosci. 2019;12:200 pubmed publisher
	Gorecki A, Preskey L, Bakeberg M, Kenna J, Gildenhuys C, MacDougall G, et al. Altered Gut Microbiome in Parkinson's Disease and the Influence of Lipopolysaccharide in a Human α-Synuclein Over-Expressing Mouse Model. Front Neurosci. 2019;13:839 pubmed publisher
	Schwab N, Tator C, Hazrati L. DNA damage as a marker of brain damage in individuals with history of concussions. Lab Invest. 2019;: pubmed publisher
	Höllerhage M, Moebius C, Melms J, Chiu W, Goebel J, Chakroun T, et al. Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells. Sci Rep. 2017;7:11469 pubmed publisher
	Coelho Cerqueira E, Carmo Gonçalves P, Pinheiro A, Cortines J, Follmer C. ?-Synuclein as an intrinsically disordered monomer--fact or artefact?. FEBS J. 2013;280:4915-27 pubmed publisher

product information

Product Type :

Antibody

Product Name :

alpha Synuclein Recombinant Rabbit Monoclonal Antibody (14H2L1)

Catalog # :

701085

Quantity :

100 µg

Price :

US 375.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:500-1:5,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:5,000

Species :

Human

Clone :

14H2L1

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Immunogen :

Peptide corresponding to amino acids 117-125 of human synuclein, alpha

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:500-1:5,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:5,000

Aliases :

Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)

more info or order :

Invitrogen product webpage