FOXP3 Recombinant Rabbit Monoclonal Antibody (5H10L18) | Invitrogen 700914 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FOXP3 Recombinant Rabbit Monoclonal Antibody (5H10L18)

catalog :

700914

quantity :

100 ug

price :

US 471.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

5H10L18

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5a western blot; mouse; 1:1000; loading ...; fig 5c western blot; human; 1:1000; loading ...; fig 4b	Lu Y, Kim N, Jiang Y, Zhang H, Zheng D, Zhu F, et al. Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function. Br J Pharmacol. 2018;175:1085-1099 pubmed publisher
	Leung C, Yang Y, Leung R, So K, Guo H, Lei M, et al. Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma. Nat Commun. 2023;14:6699 pubmed publisher
	Remic T, Sersa G, Levpuscek K, Lampreht Tratar U, Ursic Valentinuzzi K, C xf6 r A, et al. Tumor cell-based vaccine contributes to local tumor irradiation by eliciting a tumor model-dependent systemic immune response. Front Immunol. 2022;13:974912 pubmed publisher
	Di Giorgio E, Wang L, Xiong Y, Christensen L, Akimova T, Han R, et al. A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells. Front Immunol. 2021;12:703632 pubmed publisher
	Zeppellini A, Galimberti S, Leone B, Pacifico C, Riva F, Cicchiello F, et al. Comparison of tumor microenvironment in primary and paired metastatic ER+/HER2- breast cancers: results of a pilot study. BMC Cancer. 2021;21:260 pubmed publisher
	Di Giorgio E, Wang L, Xiong Y, Akimova T, Christensen L, Han R, et al. MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity. J Clin Invest. 2020;130:6242-6260 pubmed publisher
	Mazzaschi G, Milanese G, Pagano P, Madeddu D, Gnetti L, Trentini F, et al. Dataset on the identification of a prognostic radio-immune signature in surgically resected Non Small Cell Lung Cancer. Data Brief. 2020;31:105781 pubmed publisher
	Garcia Perez L, van Eggermond M, Van Roon L, Vloemans S, Cordes M, Schambach A, et al. Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID. Mol Ther Methods Clin Dev. 2020;17:666-682 pubmed publisher
	Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier U, Han R, et al. Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity. J Clin Invest. 2020;130:1830-1842 pubmed publisher
	Kerstetter Fogle A, Shukla S, Wang C, Beiss V, Harris P, Sloan A, et al. Plant Virus-Like Particle In Situ Vaccine for Intracranial Glioma Immunotherapy. Cancers (Basel). 2019;11: pubmed publisher
	Bansal S, Ismahil M, Goel M, Zhou G, Rokosh G, Hamid T, et al. Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy. Circulation. 2019;139:206-221 pubmed publisher
	De Luca R, Neri D. Potentiation of PD-L1 blockade with a potency-matched dual cytokine-antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains. Cancer Immunol Immunother. 2018;67:1381-1391 pubmed publisher

product information

Product Type :

Antibody

Product Name :

FOXP3 Recombinant Rabbit Monoclonal Antibody (5H10L18)

Catalog # :

700914

Quantity :

100 ug

Price :

US 471.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1-2 ug/mL

Species :

Human, Mouse

Clone :

5H10L18

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

Immunogen :

proprietary

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1-2 ug/mL

Aliases :

AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID

more info or order :

Invitrogen product webpage