Securin Recombinant Rabbit Monoclonal Antibody (19H16L48) | Invitrogen 700791 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Securin Recombinant Rabbit Monoclonal Antibody (19H16L48)

catalog :

700791

quantity :

100 ug

price :

US 520.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

19H16L48

reactivity :

human, mouse

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 1b	Read M, Fong J, Modasia B, Fletcher A, Imruetaicharoenchoke W, Thompson R, et al. Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. Oncogene. 2017;36:5296-5308 pubmed publisher
western blot; human; loading ...; fig s1i	Alfieri C, Chang L, Zhang Z, Yang J, Maslen S, Skehel M, et al. Molecular basis of APC/C regulation by the spindle assembly checkpoint. Nature. 2016;536:431-436 pubmed publisher
western blot; human	Takenaga M, Yamamoto Y, Takeuchi T, Ohta Y, Tokura Y, Hamaguchi A, et al. Potential new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor. Biochem Biophys Res Commun. 2015;463:222-8 pubmed publisher
	T xe1 trai P, Gergely F. Centrosome function is critical during terminal erythroid differentiation. EMBO J. 2022;41:e108739 pubmed publisher
	Blengini C, Nguyen A, Aboelenain M, Schindler K. Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B. Aging Cell. 2021;20:e13489 pubmed publisher
	Pauerova T, Radonova L, Horakova A, Knott J, Anger M. Accumulation of Securin on Spindle During Female Meiosis I. Front Cell Dev Biol. 2021;9:701179 pubmed publisher
	Alfieri C, Tischer T, Barford D. A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase. EMBO Rep. 2020;21:e49831 pubmed publisher
	Zhang S, Tischer T, Barford D. Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C. Nat Commun. 2019;10:3863 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Securin Recombinant Rabbit Monoclonal Antibody (19H16L48)

Catalog # :

700791

Quantity :

100 ug

Price :

US 520.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 2 ug/mL, Western Blot: 1-3 ug/mL

Species :

Human, Mouse

Clone :

19H16L48

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Immunogen :

A recombinant protein corresponding to amino acids 1-202.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

AW555095; C87862; EAP1; Esp1-associated protein; ESP1-associated protein 1; HPTTG; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Pttg3; Securin; tumor-transforming protein 1; TUTR1

more info or order :

Invitrogen product webpage