Connexin 46 Recombinant Rabbit Monoclonal Antibody (11H16L33)

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Connexin 46 Recombinant Rabbit Monoclonal Antibody (11H16L33)

catalog :

700384

quantity :

100 ug

price :

US 471.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

11H16L33

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200	Scheiblin D, Gao J, Caplan J, Simirskii V, Czymmek K, Mathias R, et al. Beta-1 integrin is important for the structural maintenance and homeostasis of differentiating fiber cells. Int J Biochem Cell Biol. 2014;50:132-45 pubmed publisher
immunocytochemistry; human; 1:500; fig 2	Chai Z, Goodenough D, Paul D. Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels. Mol Biol Cell. 2011;22:4503-12 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Connexin 46 Recombinant Rabbit Monoclonal Antibody (11H16L33)

Catalog # :

700384

Quantity :

100 ug

Price :

US 471.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Mouse

Applications :

Immunohistochemistry (Paraffin): 0.5-2 ug/mL, Western Blot: 1-3 ug/mL

Species :

Mouse

Clone :

11H16L33

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46 and C2P3, maps to human chromosome 13q11-q12 and encodes a 46 kDa protein. Cx46, along with Cx50, is principally expressed in the lens of the eye. Cx46 mediates intercellular interactions during development and is necessary for the survival of neural crest cells. Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency and normal lens function. Mutations of Cx46 result in severe cataracts of the lens. Individual knockouts of Cx46 and Cx50 lead to changes in the rate of lens fiber cell differentiation and cell size, thus the interaction of Cx46 and Cx50 is required for proper organization of fiber cells.

Immunogen :

A peptide corresponding to amino acids 131-144 of Q64448.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 0.5-2 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

alpha 3 connexin; Cnx46; connexin 46; connexin-46; CTRCT14; Cx43; CX46; Cxn-46; CZP3; gap junction alpha 3; gap junction alpha-3 protein; gap junction membrane channel protein alpha 3; gap junction protein alpha 3; gap junction protein, alpha 3; gap junction protein, alpha 3, 46kDa; Gja3; Gja-3

more info or order :

Invitrogen product webpage