| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 5c, 5d
| Park S, Lee C, Choi J, Kim J, Lee W, Jang T, et al. Dysadherin awakens mechanical forces and promotes colorectal cancer progression. Theranostics. 2022;12:4399-4414 pubmed publisher |
- western blot; mouse; loading ...; fig 6a
| Mondal B, Jin H, Kallappagoudar S, Sedkov Y, Martinez T, Sentmanat M, et al. The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth. elife. 2020;9: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2c
- immunohistochemistry - frozen section; human; 1:100; loading ...; fig 7s2b
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 3a, 7s2a
- western blot; human; 1:1000; loading ...; fig 4b, 6s1c
| Diaz Osterman C, Ozmadenci D, Kleinschmidt E, Taylor K, Barrie A, Jiang S, et al. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. elife. 2019;8: pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig s4b
| Lee J, Chang J, Dominguez A, Lee H, Nam S, Chang J, et al. YAP-independent mechanotransduction drives breast cancer progression. Nat Commun. 2019;10:1848 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6d
| Geng Y, Liu X, Liang J, Habiel D, Kulur V, Coelho A, et al. PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis. JCI Insight. 2019;4: pubmed publisher |
- western blot; dogs; 1:1000; loading ...; fig 7b
| Van Itallie C, Tietgens A, Aponte A, Gucek M, Cartagena Rivera A, Chadwick R, et al. MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells. J Cell Sci. 2018;131: pubmed publisher |
- western blot; human; loading ...; fig 5
| Oblinger J, Burns S, Huang J, Pan L, Ren Y, Shen R, et al. Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation. Exp Neurol. 2018;299:299-307 pubmed publisher |
- western blot; human; loading ...; fig 7d
| Lin Y, Zhen Y, Chien K, Lee I, Lin W, Chen M, et al. LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration. Mol Biol Cell. 2017;28:1054-1065 pubmed publisher |
- immunohistochemistry - frozen section; mouse; loading ...; fig 3c
- western blot; mouse; loading ...; fig 3e
| Goreczny G, Ouderkirk Pecone J, Olson E, Krendel M, Turner C. Hic-5 remodeling of the stromal matrix promotes breast tumor progression. Oncogene. 2017;36:2693-2703 pubmed publisher |
- western blot; human; loading ...; fig 2c
| Chien J, Tsen S, Chien C, Liu H, Tung C, Lin C. ?TAT1 downregulation induces mitotic catastrophe in HeLa and A549 cells. Cell Death Discov. 2016;2:16006 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; fig 5
| Budina Kolomets A, Webster M, Leu J, Jennis M, Krepler C, Guerrini A, et al. HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res. 2016;76:2720-30 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; fig 1
- western blot; human; 1:100; fig 3
| Ren K, Lu X, Yao N, Chen Y, Yang A, Chen H, et al. Focal adhesion kinase overexpression and its impact on human osteosarcoma. Oncotarget. 2015;6:31085-103 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:100
| Kaku M, Rosales Rocabado J, Kitami M, Ida T, Akiba Y, Yamauchi M, et al. Mechanical Loading Stimulates Expression of Collagen Cross-Linking Associated Enzymes in Periodontal Ligament. J Cell Physiol. 2016;231:926-33 pubmed publisher |
- immunocytochemistry; rat; fig 5c
| Jiang J, Zhang Z, Yuan X, Poo M. Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons. J Cell Biol. 2015;209:759-74 pubmed publisher |
- western blot; human; fig 3, 4
| Puig M, Lugo R, Gabasa M, Giménez A, Velásquez A, Galgoczy R, et al. Matrix stiffening and β1 integrin drive subtype-specific fibroblast accumulation in lung cancer. Mol Cancer Res. 2015;13:161-73 pubmed publisher |
| Ignjatovi x107 Joci x107 V, Jankovi x107 Milju x161 J, I x161 i x107 Den x10d i x107 T, x17d ivaljevi x107 V, Tati x107 S, x110 ori x107 I, et al. Expression of pY397-FAK and Its miR Regulators Drive Dedifferentiation in the Thyroid Neoplasia Spectrum. Cells. 2023;12: pubmed publisher |
| Mori N, Jin J, Krishnamachary B, Mironchik Y, Wildes F, Vesuna F, et al. Functional roles of FAP-α in metabolism, migration and invasion of human cancer cells. Front Oncol. 2023;13:1068405 pubmed publisher |
| Alcantara M, Suzuki K, Acebedo A, Kajioka D, Hirohata S, Kaisho T, et al. Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice. iScience. 2022;25:105609 pubmed publisher |
| Ko S, Jung K, Yoon Y, Han B, Park M, Lee Y, et al. A novel DDR1 inhibitor enhances the anticancer activity of gemcitabine in pancreatic cancer. Am J Cancer Res. 2022;12:4326-4342 pubmed |
| Betriu N, Andreeva A, Alonso A, Semino C. Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds. Biomedicines. 2022;10: pubmed publisher |
| Cuellar Vite L, Weber Bonk K, Abdul Karim F, Booth C, Keri R. Focal Adhesion Kinase Provides a Collateral Vulnerability That Can Be Leveraged to Improve mTORC1 Inhibitor Efficacy. Cancers (Basel). 2022;14: pubmed publisher |
| Levin M, Spiro R, Jain H, Falk M. Effects of Titanium Implant Surface Topology on Bone Cell Attachment and Proliferation in vitro. Med Devices (Auckl). 2022;15:103-119 pubmed publisher |
| Choi S, Kim J, Chen C, Wu C, Marco M, Barriga F, et al. KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer. Mol Cancer Res. 2022;20:1305-1319 pubmed publisher |
| Bachmann M, Skripka A, Weißenbruch K, Wehrle Haller B, Bastmeyer M. Phosphorylated paxillin and phosphorylated FAK constitute subregions within focal adhesions. J Cell Sci. 2022;135: pubmed publisher |
| DeCastro A, Pranda M, Gray K, Merlo Coyne J, Girma N, Hurwitz M, et al. Morphological Phenotyping of Organotropic Brain- and Bone-Seeking Triple Negative Metastatic Breast Tumor Cells. Front Cell Dev Biol. 2022;10:790410 pubmed publisher |
| Brazzo J, Biber J, Nimmer E, Heo Y, Ying L, Zhao R, et al. Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation. J Cell Sci. 2021;134: pubmed publisher |
| Kawakami M, Mustachio L, Chen Y, Chen Z, Liu X, Wei C, et al. A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers. Mol Cancer Ther. 2021;20:477-489 pubmed publisher |
| Arous C, Mizgier M, Rickenbach K, Pinget M, Bouzakri K, Wehrle Haller B. Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells. J Biol Chem. 2020;295:16510-16528 pubmed publisher |
| Liu Y, Li L, Liu X, Wang Y, Liu L, Peng L, et al. Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling. elife. 2020;9: pubmed publisher |
| Khadilkar R, Ho K, Venkatesh B, Tanentzapf G. Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis. Curr Biol. 2020;30:3316-3329.e5 pubmed publisher |
| Kullmann J, Trivedi N, Howell D, Laumonnerie C, Nguyen V, Banerjee S, et al. Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit. Neuron. 2020;106:607-623.e5 pubmed publisher |
| Hou Y, Xie W, Yu L, Camacho L, Nie C, Zhang M, et al. Surface Roughness Gradients Reveal Topography-Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells. Small. 2020;16:e1905422 pubmed publisher |
| Aye J, Stafman L, Williams A, Garner E, Stewart J, Anderson J, et al. The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor. Oncotarget. 2019;10:5534-5548 pubmed publisher |
| Shannon M, Pineau J, Griffié J, Aaron J, Peel T, Williamson D, et al. Differential nanoscale organisation of LFA-1 modulates T-cell migration. J Cell Sci. 2019;133: pubmed publisher |
| Garg A, Jones T, Moss S, Mishra S, Kaul K, Ahirwar D, et al. Electromagnetic fields alter the motility of metastatic breast cancer cells. Commun Biol. 2019;2:303 pubmed publisher |
| Stowers R, Shcherbina A, Israeli J, Gruber J, Chang J, Nam S, et al. Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility. Nat Biomed Eng. 2019;3:1009-1019 pubmed publisher |
| Palamà I, D Amone S, Ratano P, Donatelli A, Liscio A, Antonacci G, et al. Mechanical Durotactic Environment Enhances Specific Glioblastoma Cell Responses. Cancers (Basel). 2019;11: pubmed publisher |
| Kim T, Lei L, Seong J, Suh J, Jang Y, Jung S, et al. Matrix Rigidity-Dependent Regulation of Ca2+ at Plasma Membrane Microdomains by FAK Visualized by Fluorescence Resonance Energy Transfer. Adv Sci (Weinh). 2019;6:1801290 pubmed publisher |
| Topal T, Kim B, Villa Diaz L, Deng C, Takayama S, Krebsbach P. Rapid translocation of pluripotency-related transcription factors by external uniaxial forces. Integr Biol (Camb). 2019;: pubmed publisher |
| Liu S, Hsu T, Chang Y, Chung A, Jiang S, OuYang C, et al. Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling. Nat Commun. 2018;9:5105 pubmed publisher |
| Haage A, Goodwin K, Whitewood A, Camp D, Bogutz A, Turner C, et al. Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo. Cell Rep. 2018;25:2401-2416.e5 pubmed publisher |
| Wu W, Liao Y. Downregulation of C-Terminal Tensin-Like Protein (CTEN) Suppresses Prostate Cell Proliferation and Contributes to Acinar Morphogenesis. Int J Mol Sci. 2018;19: pubmed publisher |
| Topal T, Hong X, Xue X, Fan Z, Kanetkar N, Nguyen J, et al. Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation. Sci Rep. 2018;8:12977 pubmed publisher |
| Gulvady A, Dubois F, Deakin N, Goreczny G, Turner C. Hic-5 expression is a major indicator of cancer cell morphology, migration, and plasticity in three-dimensional matrices. Mol Biol Cell. 2018;29:1704-1717 pubmed publisher |
| Ho L, Skiba N, Ullmer C, Rao P. Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2018;59:1969-1984 pubmed publisher |
| Millar M, Corson N, Xu L. The Adhesion G-Protein-Coupled Receptor, GPR56/ADGRG1, Inhibits Cell-Extracellular Matrix Signaling to Prevent Metastatic Melanoma Growth. Front Oncol. 2018;8:8 pubmed publisher |
| Sun S, Wu H, Guan J. Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice. Sci Rep. 2018;8:2550 pubmed publisher |
| Chang T, Chen C, Lee M, Chang Y, Lu C, Lu S, et al. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. elife. 2017;6: pubmed publisher |
| Gabasa M, Duch P, Jorba I, Giménez A, Lugo R, Pavelescu I, et al. Epithelial contribution to the profibrotic stiff microenvironment and myofibroblast population in lung fibrosis. Mol Biol Cell. 2017;28:3741-3755 pubmed publisher |
| Kuenzi B, Remsing Rix L, Stewart P, Fang B, Kinose F, Bryant A, et al. Polypharmacology-based ceritinib repurposing using integrated functional proteomics. Nat Chem Biol. 2017;13:1222-1231 pubmed publisher |
| Cavazzoni A, La Monica S, Alfieri R, Ravelli A, Van Der Steen N, Sciarrillo R, et al. Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN. Oncotarget. 2017;8:53068-53083 pubmed publisher |
| Zak T, Koshman Y, Samarel A, Robia S. Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor. Biochemistry. 2017;56:4722-4731 pubmed publisher |
| Rodriguez D, Braden B, Boyer S, Taketa D, Setar L, Calhoun C, et al. In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate. Mol Biol Cell. 2017;28:1883-1893 pubmed publisher |
| Swaminathan V, Fischer R, Waterman C. The FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin. Mol Biol Cell. 2016;27:1085-100 pubmed publisher |
| Zaman G, Sunters A, Galea G, Javaheri B, Saxon L, Moustafa A, et al. Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent. J Biol Chem. 2012;287:3946-62 pubmed publisher |
